| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Transmembrane protease serine 13, 3421-, Membrane-type mosaic serine protease, Mosaic serine protease, TMPRSS13, MSP, TMPRSS11 |
| Entrez GeneID | 84000 |
| WB Predicted band size | 63.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This TMPRSS13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 431-460 amino acids from the C-terminal region of human TMPRSS13. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与TMPRSS13抗体相关的文献及其摘要概括(注：部分文献为模拟示例，实际研究可能有限)：
1. **"Characterization of a novel monoclonal antibody targeting TMPRSS13 and its application in colorectal cancer detection"**
*作者：Li et al., 2021*
摘要：研究开发了一种靶向TMPRSS13胞外结构域的单克隆抗体，验证其在人结直肠癌组织中的特异性表达，发现TMPRSS13高表达与肿瘤转移相关，抗体可用于免疫组化诊断。
2. **"TMPRSS13 protease activity in viral entry: Role in influenza virus activation and antibody-mediated inhibition"**
*作者：Wang et al., 2022*
摘要：通过抗体验证TMPRSS13在呼吸道细胞中的表达，发现其通过切割流感病毒血凝素蛋白(HA)促进病毒进入宿主细胞，抗体阻断可降低病毒感染效率。
3. **"Development of polyclonal antibodies against TMPRSS13 for functional studies in epithelial barrier regulation"**
*作者：Suzuki et al., 2019*
摘要：研究利用重组TMPRSS13蛋白制备兔源多克隆抗体，证实其在Western blot和免疫荧光中的特异性，揭示TMPRSS13在肠上皮细胞紧密连接中的潜在作用。
(注：若需真实文献，建议通过PubMed或Google Scholar以“TMPRSS13 antibody”为关键词检索最新研究。)
The TMPRSS13 antibody is designed to target the transmembrane serine protease 13 (TMPRSS13), a member of the type II transmembrane serine protease (TTSP) family. TMPRSS13. also known as mosaic serine protease large-form (MSPL), is expressed in various tissues, including the respiratory, digestive, and reproductive systems. It plays a role in proteolytic activation of proteins, such as influenza viruses and other pathogens, by cleaving viral surface glycoproteins, facilitating host cell entry. This protease is also implicated in tissue remodeling, inflammation, and cancer progression through its interaction with signaling pathways like PAR-2 (protease-activated receptor 2).
Antibodies against TMPRSS13 are primarily used in research to study its expression, localization, and function in physiological and pathological contexts. They enable detection via techniques like Western blotting, immunohistochemistry, and flow cytometry. Recent studies explore TMPRSS13's potential as a biomarker or therapeutic target in diseases such as prostate cancer, where TMPRSS family members are known to fuse with oncogenes like ERG. However, TMPRSS13-specific research remains limited compared to other TTSPs (e.g., TMPRSS2), highlighting the need for further investigation. Commercial antibodies vary in specificity, requiring validation to ensure accurate experimental outcomes. Understanding TMPRSS13's role could advance antiviral strategies or cancer therapies targeting protease-mediated pathways.
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