| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3, Phosphoinositide phospholipase C-delta-3, Phospholipase C-delta-3, PLC-delta-3, PLCD3, KIAA1964 |
| Entrez GeneID | 113026 |
| WB Predicted band size | 89.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | This PLCD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 60-89 amino acids from the N-terminal region of human PLCD3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PLCD3(N-term)抗体的3篇参考文献的简要信息：
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1. **文献名称**: "Phospholipase C Delta 3 Regulates Skin Tumorigenesis via Interaction with the Wnt/β-Catenin Pathway"
**作者**: Li Y, et al.
**摘要**: 研究通过使用PLCD3(N-term)特异性抗体，揭示PLCD3在皮肤鳞状细胞癌中通过抑制Wnt/β-catenin信号通路发挥抑癌作用，抗体用于Western blot和免疫组化验证蛋白表达水平。
2. **文献名称**: "PLCD3 Modulates Autophagy in Cardiomyocytes and Protects Against Myocardial Ischemia-Reperfusion Injury"
**作者**: Wang H, et al.
**摘要**: 该研究利用靶向PLCD3 N端的抗体，在小鼠模型中证明PLCD3通过调控自噬减轻心肌缺血再灌注损伤，抗体用于免疫荧光和Co-IP实验验证蛋白定位及相互作用。
3. **文献名称**: "Epigenetic Silencing of PLCD3 Promotes Colorectal Cancer Metastasis via MAPK Signaling"
**作者**: Zhang R, et al.
**摘要**: 通过PLCD3(N-term)抗体的免疫印迹分析，发现结直肠癌中PLCD3表达受DNA甲基化抑制，其缺失激活MAPK通路促进转移，抗体用于临床样本的蛋白表达相关性研究。
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注：以上文献为虚拟示例，实际引用时需以真实发表的论文为准。建议通过PubMed或Google Scholar以“PLCD3 antibody N-terminal”为关键词检索最新研究。
The PLCD3 (N-term) antibody is designed to target the N-terminal region of phospholipase C delta 3 (PLCD3), a member of the phospholipase C (PLC) enzyme family. PLCD3 is involved in intracellular signaling by hydrolyzing phosphatidylinositol 4.5-bisphosphate (PIP2) into secondary messengers, inositol 1.4.5-trisphosphate (IP3) and diacylglycerol (DAG), which regulate calcium release and protein kinase C activation, respectively. This antibody is commonly used in research applications like Western blotting, immunohistochemistry, and immunofluorescence to detect PLCD3 expression and localization in various tissues or cell types.
PLCD3 plays roles in cellular processes such as proliferation, differentiation, and apoptosis. While its exact physiological functions remain less characterized compared to other PLC isoforms (e.g., PLCβ or PLCγ), studies suggest its involvement in immune responses, neural development, and cancer progression. The N-terminal region of PLCD3 contains critical domains for enzymatic activity and interaction with regulatory proteins, making this antibody a tool for studying its functional mechanisms.
Research using PLCD3 (N-term) antibodies has contributed to understanding dysregulated PLCD3 expression in diseases, including certain cancers where it may act as a tumor suppressor or promoter depending on context. Validation of antibody specificity, often through knockout controls or peptide blocking assays, is essential due to potential cross-reactivity with other PLC family members. Overall, this antibody aids in elucidating PLCD3's role in signaling pathways and disease pathology.
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