| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Putative transcription factor Ovo-like 1, hOvo1, OVOL1 |
| Entrez GeneID | 5017 |
| WB Predicted band size | 30.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This OVOL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-29 amino acids from the N-terminal region of human OVOL1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于OVOL1(N-term)抗体的3篇参考文献示例(内容为虚构示例，仅供参考格式)：
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1. **文献名称**: *OVOL1 regulates epithelial-mesenchymal transition in breast cancer via transcriptional repression of Snail*
**作者**: Zhang L, et al.
**摘要**: 本研究利用OVOL1(N-term)抗体通过Western blot和免疫荧光技术，证实了OVOL1在乳腺癌细胞中通过抑制Snail表达调控EMT过程，抑制肿瘤转移。结果显示，OVOL1在低侵袭性癌细胞中高表达，并与患者预后相关。
2. **文献名称**: *Role of OVOL1 in epidermal barrier formation and skin development*
**作者**: Wang Y, et al.
**摘要**: 通过免疫组化(使用OVOL1 N-term抗体)和基因敲除小鼠模型，研究发现OVOL1在表皮分化中起关键作用。实验表明，OVOL1缺失导致角质形成细胞分化异常，皮肤屏障功能受损，提示其与遗传性皮肤病相关。
3. **文献名称**: *OVOL1 suppresses hepatocellular carcinoma progression by binding to c-Myc promoter*
**作者**: Chen H, et al.
**摘要**: 本研究采用OVOL1(N-term)抗体进行ChIP-seq和免疫沉淀实验，发现OVOL1通过直接抑制c-Myc转录活性，阻碍肝癌细胞增殖和侵袭。临床样本分析显示，OVOL1表达与肝癌分期呈负相关。
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**注意**：以上文献为示例，实际引用时需通过PubMed、Google Scholar等平台检索真实文献。可尝试以下关键词：
`"OVOL1 antibody N-term"`、`"OVOL1 immunohistochemistry"`、`"OVOL1 Western blot"`。部分抗体厂商(如CST、Abcam)官网的“参考文献”板块也可能提供相关论文。
The OVOL1 (N-term) antibody is designed to detect the N-terminal region of the OVOL1 protein, a transcription factor belonging to the OVO-like family. OVOL1 plays critical roles in epithelial development, differentiation, and maintenance by regulating genes involved in cell fate determination and epithelial-mesenchymal transition (EMT). It acts as a transcriptional repressor, often inhibiting EMT-promoting factors like ZEB1 and SNAI1. thereby preserving epithelial integrity. Dysregulation of OVOL1 has been linked to pathological conditions, including cancer progression, fibrosis, and impaired tissue repair.
The antibody is commonly used in research applications such as Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to study OVOL1 expression, localization, and DNA-binding activity. Targeting the N-terminal region ensures specificity for full-length OVOL1. minimizing cross-reactivity with truncated isoforms or homologous proteins. Validated in human, mouse, and rat samples, this tool has been instrumental in elucidating OVOL1's role in skin barrier formation, mammary gland development, and cancer metastasis. Its utility extends to both basic research and translational studies exploring OVOL1 as a potential therapeutic target or biomarker in epithelial-related diseases.
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