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Rabbit Polyclonal MouseNtrk3(N-term) Antibody

  • 中文名: Mouse Ntrk3 (N-term)抗体
  • 别    名: NT-3 growth factor receptor, GP145-TrkC, Trk-C, Neurotrophic tyrosine kinase receptor type 3, TrkC tyrosine kinase, Ntrk3, TrkC
货号: IPDX31503
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesNT-3 growth factor receptor, GP145-TrkC, Trk-C, Neurotrophic tyrosine kinase receptor type 3, TrkC tyrosine kinase, Ntrk3, TrkC
Entrez GeneID18213
WB Predicted band size92.8kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityMouse
ImmunogenThis Mouse Ntrk3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 161-188 amino acids from the N-terminal region of mouse Ntrk3.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于Mouse Ntrk3 (N-term)抗体的3篇参考文献示例(注:文献为虚构示例,仅供格式参考):

1. **《Ntrk3 Signaling in Cerebellar Development》**

*Smith A, et al.*

摘要:通过Ntrk3 (N-term)抗体的Western blot和免疫组化分析,揭示了Ntrk3在小鼠小脑颗粒细胞中的动态表达模式,表明其在神经元迁移和突触形成中的关键作用。

2. **《TrkC Isoforms in Neuroblastoma Pathogenesis》**

*Jones B, et al.*

摘要:利用N端特异性抗体检测小鼠神经母细胞瘤模型中Ntrk3的截短变体,发现其与肿瘤侵袭性相关,并验证了该抗体在流式细胞术中的特异性。

3. **《Ntrk3 Interaction Network in Alzheimer's Models》**

*Lee C, et al.*

摘要:通过抗Ntrk3 N端抗体的免疫共沉淀技术,鉴定了其与淀粉样前体蛋白(APP)的相互作用,提示Ntrk3可能参与阿尔茨海默病的tau蛋白异常磷酸化调控。

4. **《Role of Ntrk3 in Hippocampal Synaptic Plasticity》**

*Zhang D, et al.*

摘要:结合Ntrk3 (N-term)抗体的免疫荧光和电生理学方法,证明Ntrk3缺失小鼠海马区突触传递受损,强调了其在长时程增强(LTP)中的功能。

(注:实际文献需通过学术数据库检索确认。)

背景信息

The Mouse Ntrk3 (N-term) antibody is designed to detect the N-terminal region of neurotrophic tyrosine receptor kinase 3 (NTRK3), also known as TrkC, a member of the Trk receptor family. TrkC is a transmembrane glycoprotein that binds to neurotrophin-3 (NT-3) and plays critical roles in neuronal survival, differentiation, and synaptic plasticity during development. The antibody specifically recognizes the extracellular domain of the receptor, enabling the study of TrkC expression, localization, and function in various tissues. It is commonly used in applications like Western blotting, immunohistochemistry, and immunofluorescence to investigate TrkC’s involvement in neurological disorders, cancer (where NTRK3 fusions are oncogenic drivers), and developmental processes. TrkC signaling pathways, such as Ras-MAPK and PI3K-Akt, are implicated in both physiological and pathological states, making this antibody a valuable tool for research on neurotrophic signaling mechanisms. Validated for specificity in mouse models, it helps identify TrkC isoforms and assess receptor activation or truncation in disease contexts. The antibody’s relevance extends to therapeutic studies, as NTRK inhibitors are emerging targeted therapies for cancers harboring NTRK gene alterations.

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