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Rabbit Polyclonal ARC(N-term) Antibody

  • 中文名: ARC (N-term)抗体
  • 别    名: Activity-regulated cytoskeleton-associated protein, ARC/ARG31, Activity-regulated gene 31 protein homolog, Arg31, ARC {ECO:0000312|EMBL:AAG337051}
货号: IPDX31491
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesActivity-regulated cytoskeleton-associated protein, ARC/ARG31, Activity-regulated gene 31 protein homolog, Arg31, ARC {ECO:0000312|EMBL:AAG337051}
Entrez GeneID23237
WB Predicted band size45.3kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis ARC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-66 amino acids from the N-terminal region of human ARC.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于ARC(N-term)抗体的3篇参考文献的简要总结(注:文献为示例性概括,实际引用需核对原文):

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1. **文献名称**: *ARC (Apoptosis Repressor with CARD) Protein N-Terminal Domain Antibody in Cardiac Ischemia-Reperfusion Injury*

**作者**: Smith J, et al.

**摘要**: 研究使用针对ARC蛋白N端的特异性抗体,验证其在心肌细胞中的表达,并发现ARC通过抑制线粒体凋亡通路减轻缺血再灌注损伤。抗体用于Western blot和免疫荧光定位实验。

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2. **文献名称**: *N-Terminal ARC Antibody Reveals Anti-Apoptotic Role in Neuronal Cells*

**作者**: Lee S, et al.

**摘要**: 通过ARC-N端抗体证实,ARC在神经元中高表达,并与其互作蛋白(如Caspase-8)结合以阻止凋亡。研究利用该抗体进行共免疫沉淀实验,揭示其在神经退行性疾病中的保护机制。

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3. **文献名称**: *Development of a Novel ARC N-Terminal Antibody for Cancer Cell Apoptosis Assays*

**作者**: Chen R, et al.

**摘要**: 报道一种高特异性ARC-N端多克隆抗体的开发,用于检测多种癌症细胞系中ARC的差异表达。抗体在流式细胞术和免疫组化中验证,结果显示ARC高表达与化疗耐药性相关。

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(注:以上文献为模拟内容,实际研究中请通过PubMed或Google Scholar检索真实文献。)

背景信息

ARC (N-term) antibody targets the N-terminal region of the Apoptosis Repressor with CARD (ASC), also known as PYCARD or TMS1. ASC is a critical adaptor protein involved in inflammasome formation, mediating inflammatory and apoptotic signaling pathways. Its N-terminal pyrin domain (PYD) facilitates homotypic interactions with other PYD-containing proteins, such as NLRP3 and AIM2. enabling caspase-1 activation and subsequent processing of pro-inflammatory cytokines like IL-1β and IL-18. Dysregulation of ASC is linked to autoimmune disorders, cancer, and neurodegenerative diseases. The ARC (N-term) antibody is commonly used in research to detect full-length ASC or its cleavage products via techniques like Western blot, immunofluorescence, or immunohistochemistry. It helps elucidate ASC's role in inflammasome activation, apoptosis, and disease mechanisms. Validation often includes testing in ASC-deficient models to confirm specificity. Researchers rely on this antibody to study pathological conditions involving aberrant inflammasome activity, offering insights into therapeutic targeting of ASC-associated pathways.

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