| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Heterogeneous nuclear ribonucleoprotein D-like, hnRNP D-like, hnRNP DL, AU-rich element RNA-binding factor, JKT41-binding protein, Protein laAUF1, HNRNPDL, HNRPDL, JKTBP |
| Entrez GeneID | 9987 |
| WB Predicted band size | 46.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This HNRPDL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 206-234 amino acids from the Central region of human HNRPDL. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于HNRPDL抗体的3篇参考文献示例(注：以下内容为模拟生成，非真实存在的文献)：
1. **文献名称**：*HNRPDL regulates mRNA stability in cancer cells through specific AU-rich elements*
**作者**：Wang, Y., et al.
**摘要**：本研究利用HNRPDL抗体进行RNA免疫沉淀(RIP)实验，发现HNRPDL通过结合mRNA的AU富集区调控其稳定性，影响肿瘤细胞的增殖和转移。
2. **文献名称**：*Autoantibodies against HNRPDL in systemic lupus erythematosus: diagnostic implications*
**作者**：Chen, L., et al.
**摘要**：通过ELISA和蛋白质印迹法(Western blot)检测系统性红斑狼疮(SLE)患者血清中的HNRPDL自身抗体，发现其与疾病活动性显著相关，提示其作为新型生物标志物的潜力。
3. **文献名称**：*HNRPDL interacts with viral RNA to modulate host antiviral responses*
**作者**：Kim, S., et al.
**摘要**：研究通过免疫共沉淀(Co-IP)结合HNRPDL抗体，揭示HNRPDL直接结合流感病毒RNA，抑制宿主天然免疫应答，为抗病毒治疗提供新靶点。
4. **文献名称**：*Alternative splicing regulation by HNRPDL in neuronal development*
**作者**：García-Martínez, M., et al.
**摘要**：利用HNRPDL特异性抗体敲低实验，证明HNRPDL通过调控神经元前体细胞中关键基因的可变剪接，影响神经突触的形成和分化。
(注：若需真实文献，建议通过PubMed或Google Scholar以“HNRPDL antibody”或“hnRNPDL antibody”为关键词检索近年研究。)
The heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) protein, a member of the HNRNP family, is involved in RNA metabolism, including splicing, transport, stability, and translation. It contains RNA-binding motifs that enable interactions with nucleic acids, playing a role in gene expression regulation. HNRNPDL is ubiquitously expressed, with high levels in the nucleus, and dynamically shuttles between nuclear and cytoplasmic compartments depending on cellular conditions.
Mutations in the HNRNPDL gene have been linked to limb-girdle muscular dystrophy (LGMD) and Emery-Dreifuss muscular dystrophy (EDMD), highlighting its importance in muscle function. Dysregulation of HNRNPDL expression is also observed in cancers, where it may act as an oncogene or tumor suppressor, influencing cell proliferation and apoptosis.
HNRNPDL antibodies are essential tools for studying its expression, localization, and interactions in disease models. They are used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate its role in RNA processing and pathogenesis. Research using these antibodies has advanced understanding of HNRNPDL's dual roles in normal cellular processes and disease mechanisms, offering potential diagnostic or therapeutic targets for muscular dystrophies and malignancies.
×
