| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Homeobox protein Hox-A7, Homeobox protein Hox-11, Homeobox protein R5, Hoxa7, Hoxa-7 |
| WB Predicted band size | 12.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Rat |
| Immunogen | This Rat Hoxa7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of rat Hoxa7. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Rat Hoxa7 (N-term)抗体的参考文献示例(内容为虚构，仅供参考)：
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1. **"Spatiotemporal Expression of Hoxa7 in Rat Embryonic Development"**
*作者：Krumlauf, R., et al. (1998)*
**摘要**：研究利用针对Hoxa7 N端的多克隆抗体，通过免疫组化分析了大鼠胚胎发育中Hoxa7的时空表达模式，发现其在体节和神经管中特异性表达，提示其在胚胎分节中的关键作用。
2. **"Hoxa7 Antibody Validation for Cross-Species Reactivity"**
*作者：Sasaki, H., & Izpisua-Belmonte, J.C. (2003)*
**摘要**：本文描述了Rat Hoxa7 (N-term)抗体的制备与验证，证实其在大鼠和小鼠模型中均具有特异性识别能力，并成功应用于Western blot和免疫荧光，揭示Hoxa7在肢体再生中的调控机制。
3. **"Role of Hoxa7 in Axonal Guidance: Insights from Rat CNS Studies"**
*作者：Garcia-Fernàndez, J., et al. (2010)*
**摘要**：通过抗Hoxa7 N端抗体的免疫染色，研究揭示了大鼠中枢神经系统中Hoxa7在轴突导向和神经元迁移中的功能，为Hox基因在神经发育中的作用提供新证据。
4. **"Antibody-Based Screening of Hoxa7 Interactions in Rat Tissues"**
*作者：Zhang, Y., et al. (2015)*
**摘要**：利用免疫共沉淀(Co-IP)结合Rat Hoxa7 (N-term)抗体，鉴定出Hoxa7在大鼠肝脏和肾脏中与多种转录因子的相互作用，提示其参与器官特异性基因调控网络。
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*注：以上文献为示例，实际引用时需核实真实来源及内容准确性。*
The Rat Hoxa7 (N-term) antibody is a specialized tool designed to detect the N-terminal region of the Hoxa7 protein in rat tissues. Hoxa7 belongs to the Hox gene family, a highly conserved group of transcription factors critical for embryonic development, particularly in establishing body axis patterning and organogenesis. These genes encode proteins that regulate the expression of downstream target genes by binding to specific DNA sequences, thereby coordinating cellular differentiation and tissue organization. The Hoxa7 protein, part of the HoxA cluster on chromosome 6 in rodents, is implicated in anterior-posterior axis specification and limb development.
This antibody is typically generated in hosts like rabbits or mice using synthetic peptides corresponding to the N-terminal domain of rat Hoxa7. It is commonly validated for applications such as Western blotting, immunohistochemistry, and immunofluorescence to study Hoxa7 expression and localization in developmental or disease models. Researchers use it to explore Hoxa7's role in normal embryogenesis, as well as its potential dysregulation in cancers or congenital disorders, where aberrant Hox gene expression is often observed. Specificity is confirmed through knockout controls or peptide-blocking assays. As Hox proteins exhibit high structural homology across species, cross-reactivity with orthologs in other rodents (e.g., mice) is possible but requires empirical verification. The antibody serves as a key reagent in developmental biology and translational research, aiding investigations into how Hoxa7 contributes to tissue patterning and disease mechanisms.
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