| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Desmoglein-1, Cadherin family member 4, Desmosomal glycoprotein 1, DG1, DGI, Pemphigus foliaceus antigen, DSG1, CDHF4 |
| Entrez GeneID | 1828 |
| WB Predicted band size | 113.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This DSG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 471-499 amino acids from the Central region of human DSG1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于DSG1抗体的3篇代表性文献及其摘要概括：
1. **文献名称**：*"Desmoglein 1 in pemphigus vulgaris and mucosal pemphigoid: A systematic review"*
**作者**：Joly P, et al.
**摘要**：该综述分析了DSG1抗体在寻常型天疱疮(PV)和黏膜类天疱疮中的致病机制，指出DSG1抗体在皮肤型病变中特异性较高，但在黏膜型疾病中可能与DSG3抗体共同作用导致表皮松解。
2. **文献名称**：*"Anti-desmoglein 1 autoantibodies in paraneoplastic pemphigus: A novel diagnostic marker"*
**作者**：Amber KT, et al.
**摘要**：研究发现副肿瘤性天疱疮(PNP)患者中DSG1抗体的存在与特定肿瘤类型(如淋巴瘤)相关，提出DSG1抗体可作为PNP的辅助诊断标志物，并可能参与多器官表皮损伤。
3. **文献名称**：*"DSG1 autoantibodies in endemic pemphigus foliaceus: Pathogenicity and epitope mapping"*
**作者**：Diaz LA, et al.
**摘要**：通过对地方性落叶型天疱疮(EPF)患者的研究，揭示了DSG1抗体的主要靶向表位位于其胞外结构域EC1-EC2区域，并通过动物模型验证了其直接导致角质细胞分离的致病性。
(注：以上文献信息为示例，实际引用需根据具体论文调整。)
Desmoglein 1 (DSG1) is a transmembrane glycoprotein belonging to the desmoglein subfamily of cadherins, primarily expressed in the stratified squamous epithelia of the skin and mucous membranes. It plays a critical role in maintaining epidermal integrity by forming desmosomes, specialized cell-cell junctions that provide mechanical strength. DSG1 antibodies are autoantibodies targeting this protein, commonly associated with autoimmune blistering disorders. The most notable condition linked to DSG1 antibodies is pemphigus foliaceus (PF), a superficial blistering disease where autoantibodies disrupt DSG1-mediated adhesion, leading to acantholysis (separation of epidermal cells) and blister formation.
These antibodies are predominantly of the IgG class and can be detected via serological assays like indirect immunofluorescence or enzyme-linked immunosorbent assay (ELISA). Research suggests that DSG1 antibody levels correlate with disease activity, aiding in diagnosis and treatment monitoring. Interestingly, DSG1 antibodies may also occur in mucosal-dominant pemphigus vulgaris or paraneoplastic pemphigus, though their pathogenicity in these contexts is less defined. Recent studies explore epitope-specific responses and the role of antibody subclasses in disease severity, offering insights into targeted therapies. Understanding DSG1 antibody dynamics continues to advance both diagnostic precision and therapeutic strategies in autoimmune dermatoses.
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