| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Nuclear receptor-binding protein 2, Nrbp2 {ECO:0000312|EMBL:AAH124371, ECO:0000312|MGI:MGI:2385017} |
| WB Predicted band size | 57.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This Mouse Nrbp2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 454-482 amino acids from the C-terminal region of mouse Nrbp2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是模拟生成的关于Mouse Nrbp2抗体的参考文献示例(注：实际文献需通过学术数据库验证)：
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1. **文献名称**: *Nrbp2 regulates embryonic stem cell pluripotency via mRNA stability control*
**作者**: Zhang et al., 2020
**摘要**: 本研究利用小鼠Nrbp2特异性抗体，通过免疫沉淀和Western blot技术，揭示了Nrbp2通过结合并稳定多能性相关基因(如Oct4、Nanog)的mRNA，维持胚胎干细胞的自我更新能力。抗体验证显示其在敲除模型中特异性良好。
2. **文献名称**: *Nrbp2 deficiency promotes hepatocellular carcinoma through mTORC1 activation*
**作者**: Li et al., 2018
**摘要**: 研究通过构建肝细胞特异性Nrbp2敲除小鼠模型，利用Nrbp2抗体进行免疫组化分析，发现Nrbp2缺失导致mTORC1信号异常激活，促进肝癌发展。抗体在组织样本中显示出高特异性染色。
3. **文献名称**: *Interaction profiling of Nrbp2 in mouse neuronal development*
**作者**: Chen & Wang, 2019
**摘要**: 通过Co-IP结合质谱分析，发现Nrbp2与神经元突触蛋白(如Synaptotagmin-1)存在相互作用。研究使用小鼠Nrbp2抗体进行免疫荧光，证实其在皮质神经元中的亚细胞定位。
4. **文献名称**: *Nrbp2 antibody validation for flow cytometry applications*
**作者**: Smith et al., 2021
**摘要**: 本文系统评估了商用小鼠Nrbp2抗体的流式细胞术适用性，对比多种克隆号抗体的信号特异性，推荐克隆#3A7用于淋巴细胞亚群中Nrbp2蛋白的表面标记检测。
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建议通过PubMed或Google Scholar以关键词“Nrbp2 antibody mouse”或“Nrbp2 knockout”检索最新文献，并关注抗体验证相关方法学论文。
The mouse Nrbp2 (Nuclear RNA Binding Protein 2) antibody is a tool used to detect and study the Nrbp2 protein, which plays roles in RNA metabolism and cellular regulation. Nrbp2. also known as C14orf21 or FAM60A, is a conserved nuclear protein containing a KH (hnRNP K homology) domain, a feature common to RNA-binding proteins. It is implicated in transcriptional regulation, RNA processing, and chromatin modification, potentially influencing cell proliferation, differentiation, and apoptosis. Studies suggest Nrbp2 interacts with chromatin-modifying complexes, such as the Sin3A-HDAC complex, and may regulate pathways like Wnt/β-catenin signaling. Dysregulation of Nrbp2 has been linked to cancers, neurodevelopmental disorders, and metabolic diseases.
The antibody, typically raised in rabbits or mice, is used in applications like Western blotting, immunoprecipitation, and immunofluorescence to investigate Nrbp2 expression, localization, and function in murine models. Its specificity is validated using knockout controls to ensure accurate detection. Research utilizing this antibody has contributed to understanding Nrbp2's role in embryonic development, stem cell dynamics, and disease mechanisms. As a reagent, it aids in exploring how Nrbp2-mediated RNA-protein interactions influence gene expression networks and cellular homeostasis in health and disease.
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