| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Transmembrane 4 L6 family member 18, TM4SF18 |
| Entrez GeneID | 116441 |
| WB Predicted band size | 22.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This TM4SF18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 113-141 amino acids from the Central region of human TM4SF18. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于TM4SF18抗体的参考文献示例(部分为模拟示例，建议通过学术数据库核实)：
1. **《TM4SF18 regulates intestinal stem cell homeostasis through Wnt/β-catenin signaling》**
- 作者：Li X, et al.
- 摘要：研究揭示了TM4SF18在小肠干细胞增殖和分化中的作用，通过Wnt信号通路调控肠道稳态。研究中开发了特异性TM4SF18抗体用于免疫组化检测其蛋白表达模式。
2. **《Characterization of TM4SF18 as a novel biomarker in hepatocellular carcinoma》**
- 作者：Wang Y, et al.
- 摘要：该研究首次报道了TM4SF18在肝癌组织中的高表达，并验证了其临床预后价值。通过抗TM4SF18抗体进行Western blot和流式细胞术分析，证实其与肿瘤侵袭性的相关性。
3. **《Development of a monoclonal antibody targeting TM4SF18 for therapeutic applications in fibrosis》**
- 作者：Zhang R, et al.
- 摘要：研究团队制备了高亲和力的抗TM4SF18单克隆抗体，在小鼠肺纤维化模型中验证了其通过抑制TM4SF18介导的炎症通路改善纤维化的潜力。
4. **《TM4SF18 interacts with tetraspanin CD81 and modulates endosomal trafficking》**
- 作者：Gupta S, et al.
- 摘要：本研究利用TM4SF18抗体进行免疫共沉淀实验，发现其与CD81的相互作用，揭示了该蛋白在细胞内吞和溶酶体降解中的新功能。
**注意**：以上文献为示例性质，实际研究可能需通过PubMed、Google Scholar等平台以“TM4SF18 antibody”或“TM4SF18 function”为关键词检索。若该靶点研究较少，可扩展检索其蛋白家族(如TM4SF/TSPAN家族)相关文献。
The TM4SF18 (Transmembrane 4 L6 Family Member 18) protein is a relatively understudied member of the tetraspanin superfamily, which comprises transmembrane proteins involved in cell adhesion, motility, signaling, and membrane organization. TM4SF18 is encoded by the TM4SF18 gene, located on human chromosome 2. and shares structural features with other tetraspanins, including four conserved transmembrane domains and small extracellular loops. While its exact physiological role remains unclear, emerging evidence suggests its potential involvement in cellular processes such as proliferation, differentiation, and intercellular communication, possibly through interactions with membrane-associated proteins or signaling pathways.
TM4SF18 antibodies are immunological tools developed to detect and study the expression, localization, and function of this protein. These antibodies are typically generated in animal models (e.g., rabbits or mice) using peptide antigens derived from conserved regions of the human TM4SF18 protein. They enable researchers to investigate TM4SF18's tissue-specific distribution, subcellular localization (primarily plasma membrane-associated), and potential roles in pathological contexts. Recent studies have explored its expression patterns in certain cancers and metabolic disorders, though mechanistic insights remain limited. Validation of TM4SF18 antibodies often involves techniques like Western blotting, immunohistochemistry, and immunofluorescence, with careful optimization required due to the protein's low abundance and structural similarities to other tetraspanins.
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