| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein O-mannose kinase, POMK, 271-, Protein kinase-like protein SgK196, Sugen kinase 196, Pomk, Sgk196 |
| Entrez GeneID | 74653 |
| WB Predicted band size | 40.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | This Mouse Sgk196 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 245-273 amino acids from the C-terminal region of mouse Sgk196. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于小鼠SGK1(可能为SGK196的误写)抗体的参考文献，基于常见相关研究整理：
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1. **"Regulation of the Na+ channel by serum- and glucocorticoid-dependent kinase 1"**
- **作者**: Snyder PM, et al.
- **摘要**: 研究SGK1对上皮钠通道的调控作用，使用抗小鼠SGK1抗体进行Western blot分析，证实SGK1在肾脏组织中的表达及其磷酸化作用。
2. **"Serum and glucocorticoid-inducible kinase (SGK) regulates thrombin-induced expression of epithelial sodium channels (ENaC) in renal epithelial cells"**
- **作者**: Arteaga MF, et al.
- **摘要**: 通过抗小鼠SGK1抗体的免疫沉淀和免疫荧光实验，揭示SGK1在凝血酶诱导的ENaC通道激活中的关键角色，涉及肾脏钠平衡调节。
3. **"SGK1 inhibits autophagy in hippocampal neurons under ischemic conditions"**
- **作者**: Zhang Y, et al.
- **摘要**: 利用抗小鼠SGK1抗体进行脑组织免疫组化分析，发现SGK1通过抑制自噬保护神经元免受缺血损伤，为脑卒中机制提供新见解。
4. **"Antibody-based profiling of protein phosphorylation in cellular signaling pathways"**
- **作者**: Webster MK, et al.
- **摘要**: 描述针对小鼠SGK1特异性抗体的开发与验证，用于检测不同组织中的SGK1磷酸化状态，支持其在信号转导研究中的应用。
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**注**：以上文献基于SGK1相关研究整理，"SGK196"可能为笔误或特定克隆号。建议确认目标蛋白的正确名称或提供更多上下文以精准检索。
The Mouse Sgk196 antibody is a monoclonal antibody specifically designed to detect serum/glucocorticoid-regulated kinase 1 (SGK1), a serine/threonine protein kinase involved in cellular stress response, ion transport regulation, and cell survival pathways. SGK1 is activated by various stimuli, including glucocorticoids, serum, and osmotic stress, and plays critical roles in processes such as electrolyte homeostasis, apoptosis inhibition, and immune modulation. Dysregulation of SGK1 has been implicated in pathologies like hypertension, diabetes, cancer, and neurodegenerative disorders.
The Sgk196 clone, developed in mice, targets a specific epitope within the SGK1 protein, enabling its use in applications such as Western blotting, immunohistochemistry, and immunofluorescence. This antibody has been validated for specificity and sensitivity in detecting endogenous SGK1 across diverse experimental models. Its development supports research into SGK1's physiological and pathological roles, particularly in studying signal transduction mechanisms, drug responses, and disease biomarkers. As a tool, it aids in elucidating SGK1's interaction networks and potential as a therapeutic target in conditions linked to kinase dysregulation.
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