| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MAPK/MAK/MRK overlapping kinase, MOK protein kinase, Serine/threonine kinase 30, Mok, Rage, Stk30 |
| Entrez GeneID | 26448 |
| WB Predicted band size | 48.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This Mouse Rage antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 76-104 amino acids from the N-terminal region of mouse Rage. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是基于学术文献结构的模拟参考文献示例(注：实际文献可能不存在，仅供格式参考)：
1. **《RAGE-N-terminal antibody validation in diabetic mouse models》**
- 作者：Chen L, et al.
- 摘要：验证了抗小鼠RAGE-N端抗体的特异性，证明其在糖尿病模型肾脏组织Western blot和免疫荧光中的有效性，揭示RAGE在糖尿病肾病中的高表达。
2. **《N-terminal RAGE antibody application in neuroinflammation studies》**
- 作者：Kimura H, et al.
- 摘要：利用该抗体检测阿尔茨海默病小鼠脑脊液RAGE水平，证实其与β-淀粉样蛋白沉积的相关性，为靶向RAGE治疗提供依据。
3. **《Role of RAGE in tumor microenvironment: Antibody-based analysis》**
- 作者：Gonzalez RR, et al.
- 摘要：通过该抗体发现RAGE在胰腺癌小鼠肿瘤基质中高表达，阻断RAGE-N端可抑制肿瘤生长，提示其作为癌症治疗靶点的潜力。
4. **《Comparative study of RAGE antibodies in cardiovascular research》**
- 作者：Wang Y, et al.
- 摘要：对比多种RAGE抗体性能，确认N-term抗体在动脉粥样硬化小鼠模型中的可靠性，发现RAGE与血管炎症标志物的共定位关系。
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**提示**：
1. 实际文献需通过PubMed/Google Scholar以关键词“mouse RAGE antibody N-terminal”检索。
2. 可关注抗体生产商(如Cell Signaling、Abcam)的技术文档，获取已验证的引用文献。
3. 若研究领域特殊，建议补充疾病类型或实验方法缩小检索范围。
**Background of Mouse RAGE (N-Terminus) Antibody**
The Mouse RAGE (Receptor for Advanced Glycation End-products) antibody targeting the N-terminal region is a key tool for studying the role of RAGE in various pathological and physiological processes. RAGE, a transmembrane receptor belonging to the immunoglobulin superfamily, is implicated in inflammation, diabetic complications, neurodegenerative disorders, and cancer. It binds diverse ligands, including advanced glycation end products (AGEs), S100 proteins, and HMGB1. activating downstream signaling pathways like NF-κB, which drive oxidative stress and pro-inflammatory responses.
The N-terminal domain of RAGE is critical for ligand binding and receptor oligomerization. Antibodies specific to this region are designed to detect full-length RAGE or its soluble isoforms (sRAGE), which lack the transmembrane domain and act as decoy receptors. Mouse-specific RAGE antibodies enable researchers to investigate tissue-specific expression, ligand-receptor interactions, and RAGE-mediated signaling in murine models of disease, such as atherosclerosis, Alzheimer’s disease, or diabetes.
These antibodies are validated for applications like Western blotting, immunohistochemistry, and flow cytometry, often with knockout controls to ensure specificity. By targeting the N-terminus, they avoid cross-reactivity with other immunoglobulin-like receptors, providing reliable data for studies exploring RAGE as a therapeutic target or biomarker in chronic inflammatory and age-related diseases.
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