| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Serine/threonine-protein kinase greatwall, GW, GWL, Microtubule-associated serine/threonine-protein kinase-like, MAST-L, Mastl, Gw, Gwl |
| Entrez GeneID | 67121 |
| WB Predicted band size | 96.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This Mouse Mastl antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 561-589 amino acids from the Central region of mouse Mastl. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Mouse Mastl抗体的3篇参考文献示例(基于公开信息模拟，非真实文献)：
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1. **文献名称**：*Mastl kinase regulates mitotic progression in mouse embryonic fibroblasts*
**作者**：Smith J, et al.
**摘要**：研究利用特异性Mouse Mastl抗体分析Mastl蛋白在细胞周期中的定位，发现其通过调控ENSA/PP2A-B55通路影响有丝分裂进程，敲除Mastl导致G2/M期阻滞和染色体分离异常。
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2. **文献名称**：*Development and validation of a monoclonal antibody against murine Mastl for cancer studies*
**作者**：Li X, et al.
**摘要**：报道一种高特异性Mouse Mastl单克隆抗体的开发，通过免疫印迹和免疫荧光验证其在乳腺癌模型中的应用，揭示Mastl过表达与肿瘤细胞增殖及化疗耐药性的相关性。
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3. **文献名称**：*Mastl deficiency triggers DNA damage response in mouse liver tissues*
**作者**：Garcia R, et al.
**摘要**：利用Mastl抗体进行组织染色，发现Mastl敲除小鼠肝脏中γH2AX水平升高，表明DNA损伤应答激活，提示Mastl在维持基因组稳定性中的关键作用。
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如需具体文献，建议通过PubMed或Web of Science以“Mastl antibody”及“mouse”为关键词检索，并筛选涉及抗体开发、验证或应用的实验研究。
The mouse Mastl (Microtubule-associated serine/threonine kinase-like) antibody is a tool used to study the Mastl protein, a conserved serine/threonine kinase critical in cell cycle regulation, particularly during the G2/M transition and mitotic exit. Mastl, also known as Greatwall kinase, plays a key role in maintaining CDK1 activity by suppressing the PP2A-B55 phosphatase complex, ensuring proper mitotic progression and genome stability. Dysregulation of Mastl is linked to mitotic errors, chromosomal instability, and cancer development.
Mouse Mastl antibodies are widely employed in research to investigate DNA damage response, checkpoint control, and cell division mechanisms. These antibodies enable detection and localization of Mastl in mouse tissues or cell lines via techniques like Western blotting, immunofluorescence, and immunoprecipitation. Studies using Mastl-deficient models highlight its essential role in embryonic development and tumor suppression. Structurally, Mastl contains a kinase domain and regulatory regions, with phosphorylation sites modulating its activity during the cell cycle.
Research utilizing Mouse Mastl antibodies has advanced understanding of how cells maintain genomic integrity under stress and how its dysfunction contributes to diseases. Its role as a potential therapeutic target in cancers or mitotic disorders remains an active area of study, emphasizing the antibody's value in both basic and translational research contexts.
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