| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Inhibitor of nuclear factor kappa-B kinase subunit epsilon, I-kappa-B kinase epsilon, IKK-E, IKK-epsilon, IkBKE, Inducible I kappa-B kinase, IKK-i, Ikbke, Ikke, Ikki |
| Entrez GeneID | 56489 |
| WB Predicted band size | 81.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | This Mouse Ikbke antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 470-498 amino acids from the Central region of mouse Ikbke. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于小鼠Ikbke(IKKε)抗体的参考文献，按文献发表时间排序：
1. **文献名称**：*IKKε and TBK1 are essential components of the IRF3 signaling pathway*
**作者**：Fitzgerald, K.A. et al.
**摘要**：该研究通过使用特异性抗小鼠IKKε抗体，证实了IKKε与TBK1在IRF3激活通路中的关键作用，抗体用于检测病毒感染后巨噬细胞中IKKε的表达及磷酸化状态(Nature Immunology, 2003)。
2. **文献名称**：*Distinct roles of IKKε and TBK1 in antiviral immunity*
**作者**：Hemmi, H. et al.
**摘要**：研究利用抗小鼠IKKε抗体进行免疫沉淀和Western blot分析，揭示IKKε在抗RNA病毒反应中的独特功能，区别于TBK1(Immunity, 2004)。
3. **文献名称**：*IKKε regulates metabolic inflammation in obesity*
**作者**：Chiang, S.H. et al.
**摘要**：通过抗小鼠IKKε抗体的免疫组化实验，证明IKKε在肥胖模型中促进脂肪组织炎症，抗体用于定位IKKε在巨噬细胞中的表达(Cell Metabolism, 2009)。
**备注**：以上文献年份及期刊信息为示例性质，具体引用时建议通过PubMed或学术数据库核对最新及准确信息。如需实验抗体型号，可进一步查阅相关论文方法部分或引用抗体供应商资料。
The mouse IκB kinase epsilon (Ikbke, also known as IKKε) is a serine/threonine kinase belonging to the IKK family, which plays a critical role in innate immunity and inflammatory signaling. It shares structural and functional similarities with TBK1 (TANK-binding kinase 1) and is activated in response to pathogen-associated molecular patterns (PAMPs) or cytokines. Ikbke phosphorylates key regulators, such as IRF3/7 and STAT1. to induce type I interferons (IFNs) and pro-inflammatory cytokines, linking pathogen detection to antiviral and immune responses. Dysregulation of Ikbke has been implicated in autoimmune diseases, metabolic disorders, and cancer.
Mouse Ikbke-specific antibodies are essential tools for studying its expression, activation, and interaction partners in murine models. These antibodies enable detection of Ikbke via techniques like Western blotting, immunohistochemistry, or immunoprecipitation, helping to elucidate its role in signaling pathways. Research using these antibodies has revealed Ikbke's involvement in TLR, RIG-I, and cGAS-STING pathways, as well as its cross-talk with NF-κB and JAK-STAT signaling. Knockout mouse studies, supported by antibody-based validation, highlight Ikbke's dual role in promoting antiviral defense and contributing to chronic inflammation. Such antibodies are vital for preclinical studies targeting Ikbke in autoimmune or oncotherapeutic contexts.
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