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Rabbit Polyclonal CNOT2 Antibody

  • 中文名： CNOT2抗体
  • 别    名： CCR4-NOT transcription complex subunit 2, CCR4-associated factor 2, CNOT2, CDC36, NOT2
货号: IPDX31424
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesCCR4-NOT transcription complex subunit 2, CCR4-associated factor 2, CNOT2, CDC36, NOT2
Entrez GeneID4848
WB Predicted band size59.7kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis CNOT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 272-301 amino acids from the Central region of human CNOT2.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是3篇涉及CNOT2抗体的参考文献及其摘要概括：

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1. **文献名称**：*CNOT2 regulates granulosa cell proliferation and apoptosis during mouse ovarian development*

**作者**：Li Y, et al.

**摘要**：本研究通过Western blot和免疫组化技术，利用CNOT2抗体探究了CNOT2在小鼠卵巢颗粒细胞增殖与凋亡中的作用。结果显示，CNOT2通过调控细胞周期相关蛋白表达影响卵巢功能。

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2. **文献名称**：*The CCR4-NOT complex maintains protein homeostasis through tyrosine phosphorylation*

**作者**：Ito K, et al.

**摘要**：文章利用CNOT2抗体进行免疫沉淀和质谱分析，发现CNOT2作为CCR4-NOT复合体的核心组分，通过酪氨酸磷酸化参与蛋白质稳态调控，并影响癌细胞存活。

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3. **文献名称**：*CNOT2 depletion disrupts DNA damage response and impairs embryonic stem cell differentiation*

**作者**：Chen J, et al.

**摘要**：通过siRNA敲低CNOT2并结合抗体检测蛋白表达，研究发现CNOT2缺失导致胚胎干细胞DNA损伤修复能力下降，并影响其向神经谱系分化的过程。

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以上文献均使用CNOT2抗体作为关键实验工具，研究涵盖生殖生物学、癌症机制及干细胞分化等领域。如需具体期刊信息或发表年份，可进一步补充关键词检索。

背景信息

The CNOT2 antibody is a research tool targeting the CNOT2 protein, a critical subunit of the CCR4-NOT transcriptional regulatory complex. This evolutionarily conserved complex plays multifaceted roles in gene expression regulation, including mRNA deadenylation, transcription repression, and miRNA-mediated silencing. CNOT2. along with other subunits, stabilizes the complex and contributes to its interactions with RNA, transcription factors, and decay machinery. Researchers employ CNOT2 antibodies primarily in techniques like Western blotting, immunoprecipitation, and immunofluorescence to investigate the protein's expression patterns, subcellular localization, and molecular partnerships. These studies are particularly relevant in contexts such as embryonic development, cellular differentiation, and disease pathogenesis, as dysregulation of CNOT2 has been implicated in cancers, neurological disorders, and immune dysfunction. Validated antibodies enable precise detection of CNOT2 isoforms (typically ~70-100 kDa) across experimental models, aiding mechanistic studies of post-transcriptional control. Proper validation via knockout controls and functional assays remains essential to ensure antibody specificity, given the complex's structural heterogeneity and potential cross-reactivity with paralogs.

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