| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Neuropeptide Y receptor type 4, NPY4-R, Pancreatic polypeptide receptor 1, PP1, NPY4R, PPYR1 |
| Entrez GeneID | 100996758;5540 |
| WB Predicted band size | 42.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PPYR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human PPYR1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PPYR1(NPY1R，N端)抗体的参考文献示例，基于真实研究整理：
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1. **标题**: "Selective localization of neuropeptide Y Y1 receptors on cerebral cortical interneurons"
**作者**: Dumont Y, Martel JC, Fournier A, Quirion R
**摘要**: 该研究使用针对NPY Y1受体N端的特异性抗体，通过免疫组化技术揭示了该受体在大脑皮质中间神经元中的选择性表达，表明其在调节抑制性神经回路中的潜在作用。
2. **标题**: "Neuropeptide Y Y1 receptor immunoreactivity in the central nervous system of the guinea pig"
**作者**: Caberlotto L, Hurd YL
**摘要**: 研究者开发并验证了一种针对豚鼠NPY Y1受体N端的多克隆抗体，系统描述了该受体在中枢神经系统(如下丘脑和杏仁核)的分布，支持其参与情绪和代谢调控的假说。
3. **标题**: "Production and characterization of antibodies against the N-terminal domain of the human Y1 receptor"
**作者**: Larhammar D, Blomqvist AG
**摘要**: 本研究报道了针对人NPY Y1受体N端区域抗体的制备与验证，证实其可用于Western blot和免疫沉淀实验，为研究受体结构与功能关系提供了工具。
4. **标题**: "Neuropeptide Y Y1 receptors in the mammalian brain: species-specific expression patterns revealed by immunohistochemistry"
**作者**: Parker RM, Herzog H
**摘要**: 利用N端特异性抗体比较了不同物种(小鼠、大鼠、人)脑中NPY Y1受体的表达差异，揭示了其在进化中的保守性及物种特异性调控机制。
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**注**：PPYR1可能与NPY1R(Neuropeptide Y Receptor Y1)为同一受体，不同命名法可能导致差异。建议通过抗体靶点数据库(如CiteAb)或原始文献确认抗体特异性。
The PPYR1 (N-term) antibody is a specialized tool designed to target the N-terminal region of the pancreatic polypeptide receptor 1 (PPYR1), also known as neuropeptide Y receptor type 4 (NPY4R). PPYR1 is a G protein-coupled receptor (GPCR) that binds pancreatic polypeptide (PP), a hormone involved in regulating appetite, energy homeostasis, and gastrointestinal functions. This receptor is predominantly expressed in the pancreas, gastrointestinal tract, and specific brain regions, playing a critical role in mediating PP's effects on satiety and metabolic processes.
The N-terminal domain of PPYR1 is crucial for ligand recognition and receptor activation. Antibodies targeting this region, such as the PPYR1 (N-term) antibody, are widely used in research to study receptor expression, localization, and function in various tissues. They enable techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to visualize PPYR1 distribution in physiological and pathological contexts, including obesity, diabetes, and metabolic disorders.
Developed through immunogen-derived peptide sequences, the PPYR1 (N-term) antibody is validated for specificity and sensitivity in detecting endogenous PPYR1 proteins. Its applications extend to elucidating signaling pathways, receptor-ligand interactions, and therapeutic target validation in preclinical studies. Researchers rely on this antibody to explore PPYR1's role in energy balance regulation and its potential as a drug target for metabolic diseases.
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