| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | TOM1-like protein 1, Src-activating and signaling molecule protein, Target of Myb-like protein 1, TOM1L1, SRCASM |
| Entrez GeneID | 10040 |
| WB Predicted band size | 53.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This TOM1L1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 445-474 amino acids from the C-terminal region of human TOM1L1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于TOM1L1抗体的3篇假设性文献示例(请注意，这些文献为虚构，仅供格式参考)：
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1. **文献名称**: "TOM1L1 regulates EGFR endocytosis and promotes breast cancer metastasis"
**作者**: Chen, Y., et al. (2017)
**摘要**: 本研究利用特异性TOM1L1抗体，通过免疫共沉淀和Western blot分析，揭示TOM1L1通过调控EGFR的内吞过程促进乳腺癌细胞迁移。临床样本显示TOM1L1高表达与患者生存率降低显著相关。
2. **文献名称**: "Development of a monoclonal antibody against TOM1L1 for neurodegenerative disease research"
**作者**: Martinez, R., et al. (2019)
**摘要**: 文章描述了一种新型高亲和力TOM1L1单克隆抗体的开发，并通过免疫组化验证其在阿尔茨海默病模型小鼠脑组织中的特异性标记。该抗体为研究TOM1L1在tau蛋白病理中的作用提供了工具。
3. **文献名称**: "TOM1L1 modulates TLR4 signaling in macrophages via antibody-blockade experiments"
**作者**: Kim, S., & Gupta, P. (2020)
**摘要**: 通过使用TOM1L1中和抗体阻断实验，研究发现TOM1L1与TLR4信号通路相互作用，影响巨噬细胞的炎症因子释放，提示其在先天免疫反应中的潜在调控机制。
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如需查找真实文献，建议在PubMed或Google Scholar中搜索关键词“TOM1L1 antibody”、“TOM1L1 function”或结合具体研究领域(如“cancer”“immunology”)。
TOM1L1 (Target of Myb1-like 1) is a protein encoded by the TOM1L1 gene, belonging to the TOM1 (Target of Myb1) family. It plays a role in intracellular vesicular trafficking and signal transduction by interacting with ubiquitinated proteins through its VHS (VPS27. HRS, STAM) domain. TOM1L1 is implicated in regulating endosomal sorting, receptor degradation, and immune response pathways, with potential links to cancer progression, neuronal development, and inflammatory diseases.
The TOM1L1 antibody is a laboratory-generated tool designed to detect and quantify TOM1L1 protein expression in biological samples. It is typically produced by immunizing animals with recombinant TOM1L1 protein fragments or synthetic peptides, yielding polyclonal or monoclonal antibodies. These antibodies are validated for specificity using techniques like Western blotting, immunohistochemistry (IHC), or immunofluorescence (IF), often with knockout cell controls.
In research, TOM1L1 antibodies help elucidate the protein’s role in cellular processes, such as EGFR trafficking, Toll-like receptor signaling, and autophagy. Dysregulation of TOM1L1 has been observed in cancers (e.g., breast, lung) and neurological disorders, making its antibody valuable for diagnostic or therapeutic studies. Commercial variants may vary in host species, clonality, or conjugation tags (e.g., HRP, FITC), tailored for specific experimental workflows. Proper validation remains critical to ensure reliability in detecting TOM1L1 isoforms and avoiding cross-reactivity with homologous proteins like TOM1 or TOM1L2.
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