| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Proto-oncogene Mas, MAS1, MAS |
| Entrez GeneID | 4142 |
| WB Predicted band size | 37.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This MAS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 285-314 amino acids from the C-terminal region of human MAS1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于 **MAS1抗体** 的3篇代表性文献示例(注：文献信息为模拟概括，具体文献需通过学术数据库检索确认)：
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1. **文献名称**：*"MAS1 Receptor Expression in Human Tumors: A Novel Biomarker for Angiogenesis"*
**作者**：Smith A, et al.
**摘要**：研究通过免疫组化技术检测了MAS1受体在多种实体瘤中的表达，发现其高表达与肿瘤血管生成和不良预后相关，提示MAS1可能作为抗血管治疗的潜在靶点，并开发了特异性抗体用于临床样本检测。
2. **文献名称**：*"Development of a Monoclonal Antibody Targeting MAS1 for Cardiovascular Disease Research"*
**作者**：Lee J, et al.
**摘要**：报道了一种针对MAS1受体胞外域的单克隆抗体的制备与验证，该抗体可特异性阻断MAS1与配体Angiotensin-(1-7)的结合，为研究MAS1在心血管疾病中的保护性机制提供了工具。
3. **文献名称**：*"MAS1 Antibody-Based Detection of Oncogenic Signaling in Triple-Negative Breast Cancer"*
**作者**：Gomez C, et al.
**摘要**：利用抗MAS1抗体分析三阴性乳腺癌中MAS1信号通路的激活状态，发现其通过调控ERK/MAPK通路促进肿瘤侵袭，提示靶向MAS1可能抑制转移。
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**建议**：通过 **PubMed** 或 **Google Scholar** 搜索关键词“MAS1 antibody”、“MAS1 receptor biomarker”或“MAS1 cancer/therapeutics”可获取更多最新研究。实际文献需结合具体研究需求筛选。
MAS1 antibody targets the MAS1 proto-oncogene, a G protein-coupled receptor (GPCR) encoded by the *MAS1* gene. Discovered in 1986. MAS1 was initially linked to tumorigenesis due to its oncogenic potential in vitro, though its physiological roles have since expanded. It is now recognized as a key component of the protective axis of the renin-angiotensin system (RAS), interacting with angiotensin-(1-7) [Ang-(1-7)] to counterbalance the classical RAS pathway mediated by angiotensin II. Activation of MAS1 promotes vasodilation, anti-inflammatory effects, and tissue protection, implicating it in cardiovascular homeostasis, metabolic regulation, and organ fibrosis.
MAS1 antibodies are essential tools for detecting and quantifying MAS1 expression in research settings. They enable studies on receptor localization, signaling mechanisms, and dysregulation in diseases such as hypertension, heart failure, and diabetes. Commercial MAS1 antibodies are typically validated for techniques like Western blotting, immunohistochemistry, and flow cytometry. However, variability in antibody specificity remains a challenge due to MAS1's structural homology with other GPCRs. Recent studies also explore MAS1's role in cancer progression and neuroprotection, broadening its therapeutic relevance. Reliable MAS1 antibodies thus support both basic research and drug development targeting this multifaceted receptor.
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