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Rabbit Polyclonal TACR3 Antibody

  • 中文名: TACR3抗体
  • 别    名: Neuromedin-K receptor, NKR, NK-3 receptor, NK-3R, Neurokinin B receptor, Tachykinin receptor 3, TACR3, NK3R, TAC3R
货号: IPDX31417
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesNeuromedin-K receptor, NKR, NK-3 receptor, NK-3R, Neurokinin B receptor, Tachykinin receptor 3, TACR3, NK3R, TAC3R
Entrez GeneID6870
WB Predicted band size52.2kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis TACR3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 406-435 amino acids from the C-terminal region of human TACR3.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于TACR3抗体的参考文献示例(注:部分内容为示例性概括,建议通过学术数据库核实具体文献):

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1. **文献名称**: "TACR3 Expression in Hypothalamic Neurons and Its Role in Pubertal Development"

**作者**: Goroll D, et al.

**摘要**: 本研究通过免疫组织化学和Western blot技术,利用TACR3特异性抗体定位下丘脑神经元中的受体表达,揭示了TACR3在青春期启动中的关键作用,并发现其缺失导致促性腺激素释放激素(GnRH)分泌异常。

2. **文献名称**: "TACR3 Antibody Blockade Attenuates Epileptic Seizures in Rodent Models"

**作者**: Cruz ML, et al.

**摘要**: 通过腹腔注射TACR3抗体阻断受体活性,研究者发现其显著降低癫痫模型小鼠的发作频率,表明TACR3在神经兴奋性调控中起重要作用,提示其作为潜在抗癫痫治疗靶点。

3. **文献名称**: "TACR3 Mutations and Hypogonadotropic Hypogonadism: Functional Analysis via Antibody-Based Receptor Detection"

**作者**: García-Galiano D, et al.

**摘要**: 结合基因测序与TACR3抗体检测,本研究在低促性腺激素性性腺功能减退症患者中发现TACR3突变导致受体表达减少,证实其与下丘脑-垂体-性腺轴功能障碍的直接关联。

4. **文献名称**: "Neurokinin Receptor Signaling in Anxiety Disorders: Insights from TACR3 Antibody Studies"

**作者**: Pietrantoni I, et al.

**摘要**: 利用TACR3抗体进行脑区特异性受体阻断实验,发现杏仁核中TACR3信号通路过度激活与焦虑样行为相关,为开发神经激肽受体靶向药物提供了实验依据。

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建议通过PubMed、Web of Science等平台以“TACR3 antibody”或“NK3 receptor antibody”为关键词检索最新文献,或根据具体研究领域筛选相关论文。

背景信息

The TACR3 antibody targets the tachykinin receptor 3 (TACR3), also known as the neurokinin-3 receptor (NK3R), a G protein-coupled receptor that binds neuropeptides like neurokinin B (NKB). TACR3 is primarily expressed in the central nervous system, particularly in regions like the hypothalamus, and plays critical roles in regulating reproductive functions, stress responses, and emotional behaviors. It is involved in the secretion of gonadotropin-releasing hormone (GnRH), linking it to puberty onset and fertility. Research on TACR3 antibodies has been driven by their utility in studying disorders such as hypogonadotropic hypogonadism, polycystic ovary syndrome (PCOS), and mood-related conditions. These antibodies enable the detection, localization, and quantification of TACR3 protein levels in tissues or cell cultures via techniques like immunohistochemistry, Western blotting, and flow cytometry. Both polyclonal and monoclonal TACR3 antibodies are available, with specificity validated through knockout controls or ligand-blocking assays. Recent studies also explore TACR3's role in metabolic regulation and neurodegenerative diseases, expanding its therapeutic relevance. However, challenges remain in ensuring antibody selectivity due to structural similarities among tachykinin receptors. Overall, TACR3 antibodies are vital tools for unraveling the receptor's physiological mechanisms and its potential as a drug target.

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