| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Transmembrane channel-like protein 6, Epidermodysplasia verruciformis protein 1, Protein LAK-4, TMC6, EVER1, EVIN1 |
| Entrez GeneID | 11322 |
| WB Predicted band size | 90.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This TMC6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 160-188 amino acids from the N-terminal region of human TMC6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于TMC6(N-term)抗体的参考文献示例(注：以下内容为模拟示例，具体文献需通过学术数据库验证)：
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1. **文献名称**: *"Characterization of TMC6 (N-term) antibody in epidermodysplasia verruciformis pathogenesis"*
**作者**: Smith A, et al.
**摘要**: 本研究通过Western blot和免疫组化验证了TMC6(N端)抗体在皮肤组织中的特异性，发现TMC6蛋白在疣状表皮发育不良患者中表达显著降低，提示其与HPV感染及皮肤癌变的潜在关联。
2. **文献名称**: *"Role of TMC6 in keratinocyte differentiation: Insights from antibody-based assays"*
**作者**: Lee J, et al.
**摘要**: 使用TMC6(N-term)抗体检测人表皮角质细胞中TMC6的亚细胞定位，发现其在细胞膜和核周区域富集，并证实TMC6通过调控钙离子通道参与角质细胞分化过程。
3. **文献名称**: *"TMC6 and TMC8 mutations in hereditary skin disorders: an antibody validation study"*
**作者**: Garcia R, et al.
**摘要**: 研究利用TMC6(N-term)抗体对患者皮肤活检样本进行蛋白表达分析，揭示了TMC6/TMC8复合体突变导致表皮屏障功能缺陷的分子机制。
4. **文献名称**: *"Development of a polyclonal antibody targeting the N-terminal domain of TMC6"*
**作者**: Chen X, et al.
**摘要**: 本文报道了一种针对TMC6蛋白N端结构域的多克隆抗体的制备与验证，通过ELISA和免疫荧光证实其高特异性和敏感性，适用于多种实验模型。
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建议通过PubMed或Web of Science以关键词“TMC6 antibody N-terminal”或“TMC6 epitope mapping”检索最新文献以获取准确信息。
The TMC6 (N-term) antibody is designed to target the N-terminal region of transmembrane channel-like 6 (TMC6), a protein encoded by the *TMC6* gene in humans. TMC6. along with its homolog TMC8. belongs to the TMC family of putative ion channels or transporters. These proteins are primarily studied for their role in epidermal function and genetic disorders. TMC6 is notably associated with epidermodysplasia verruciformis (EV), a rare autosomal recessive skin condition characterized by heightened susceptibility to cutaneous human papillomavirus (HPV) infections and an increased risk of non-melanoma skin cancers. Mutations in *TMC6* disrupt its interaction with TMC8. impairing keratinocyte differentiation and immune response regulation, which contributes to persistent HPV infection and malignant transformation.
The TMC6 (N-term) antibody is widely used in research to investigate protein expression, localization, and functional mechanisms in cellular and disease models. It is commonly applied in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study TMC6's role in skin biology, viral pathogenesis, and cancer development. Validated for specificity, this antibody aids in elucidating how TMC6/TMC8 complexes modulate ion transport or signaling pathways in epithelial cells. Its significance extends to exploring therapeutic targets for HPV-related malignancies and inherited skin disorders, underscoring its utility in dermatology and oncology research.
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