| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Junctional adhesion molecule B, JAM-B, Junctional adhesion molecule 2, JAM-2, Vascular endothelial junction-associated molecule, VE-JAM, CD322, JAM2, C21orf43, VEJAM |
| Entrez GeneID | 58494 |
| WB Predicted band size | 33.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This JAM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-91 amino acids from the N-terminal region of human JAM2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于JAM2(N-term)抗体的3篇参考文献的简要信息，基于公开研究整理：
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1. **文献名称**：*Junctional Adhesion Molecule-B (JAM-B) Regulates Endothelial Cell Migration Through Its Extracellular Domain*
**作者**：C. Scheiermann et al.
**摘要**：该研究使用针对JAM2 N末端的抗体，验证了JAM-B在血管内皮细胞迁移中的作用。实验表明，JAM2的胞外结构域(N端区域)通过调控细胞间黏附和信号通路，影响内皮细胞的定向迁移能力。
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2. **文献名称**：*Role of JAM2 in Leukocyte Transmigration and Lymphatic Function*
**作者**：M. Aurrand-Lions et al.
**摘要**：作者利用JAM2(N-term)特异性抗体进行免疫组化和流式分析，发现JAM2在淋巴管内皮细胞中高表达，并参与白细胞跨内皮迁移的调控，提示其在炎症和免疫应答中的关键功能。
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3. **文献名称**：*Characterization of a Novel Anti-JAM2 Monoclonal Antibody for Immunohistochemical Applications*
**作者**：K. Tanaka et al.
**摘要**：本文报道了一种新型抗JAM2 N末端单克隆抗体的开发与验证。该抗体在多种组织样本中表现出高特异性和敏感性，适用于免疫印迹(Western blot)和免疫荧光染色，为JAM2的病理生理研究提供了可靠工具。
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**备注**：若需具体文献链接或补充更多研究，可进一步提供关键词或数据库检索支持。
The JAM2 (N-term) antibody targets the N-terminal region of Junctional Adhesion Molecule 2 (JAM2), a member of the immunoglobulin superfamily involved in cell-cell adhesion and immune regulation. JAM2. also known as JAM-B or VE-JAM, is a transmembrane protein expressed on endothelial and immune cells, including lymphocytes and dendritic cells. It plays critical roles in maintaining vascular and epithelial barrier integrity, leukocyte migration, and immune synapse formation. The N-terminal extracellular domain of JAM2 mediates homophilic interactions with itself or heterophilic binding to JAM3 (JAM-C), facilitating cell adhesion and signaling.
This antibody is commonly used in research to study JAM2 localization, expression levels, and function in physiological and pathological contexts, such as inflammation, angiogenesis, and cancer metastasis. It is validated for applications like Western blotting, immunohistochemistry, and flow cytometry. Studies using JAM2 (N-term) antibodies have highlighted its involvement in autoimmune diseases, tumor microenvironment modulation, and lymphocyte trafficking. By detecting the N-terminal epitope, the antibody helps elucidate mechanisms underlying endothelial barrier disruption or immune cell recruitment in diseases like multiple sclerosis or atherosclerosis. Its specificity makes it a valuable tool for exploring JAM2's role in intercellular communication and therapeutic targeting.
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