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Rabbit Polyclonal UBP46 Antibody

  • 中文名： UBP46抗体
  • 别    名： Ubiquitin carboxyl-terminal hydrolase 46, Deubiquitinating enzyme 46, Ubiquitin thioesterase 46, Ubiquitin-specific-processing protease 46, USP46
货号: IPDX31411
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesUbiquitin carboxyl-terminal hydrolase 46, Deubiquitinating enzyme 46, Ubiquitin thioesterase 46, Ubiquitin-specific-processing protease 46, USP46
Entrez GeneID64854
WB Predicted band size42.4kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis UBP46 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 241-269 amino acids from the C-terminal region of human UBP46.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于UBP46(USP46)抗体的模拟参考文献示例(注：文献信息为假设，建议通过学术数据库核实真实研究)：

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1. **文献名称**：*"USP46 regulates synaptic plasticity through deubiquitination of AMPA receptors"*

**作者**：Smith A, et al. (2020)

**摘要**：本研究利用UBP46特异性抗体进行免疫印迹和免疫荧光实验，发现USP46通过调控AMPA受体的泛素化水平影响突触可塑性和小鼠学习记忆功能。

2. **文献名称**：*"A novel monoclonal antibody against human USP46 for cancer biomarker analysis"*

**作者**：Zhang L, et al. (2018)

**摘要**：开发了一种高特异性人源UBP46单克隆抗体，用于检测结直肠癌组织中USP46的表达，发现其低表达与患者预后不良显著相关。

3. **文献名称**：*"USP46 modulates Wnt signaling by stabilizing β-catenin in embryonic development"*

**作者**：Lee J, et al. (2019)

**摘要**：通过UBP46抗体的免疫共沉淀实验，揭示了USP46通过去泛素化β-catenin调控Wnt通路，影响斑马鱼胚胎发育的分子机制。

4. **文献名称**：*"USP46 stabilizes PERIOD proteins to maintain circadian rhythm integrity"*

**作者**：Kimura T, et al. (2017)

**摘要**：利用UBP46抗体在小鼠脑组织中的定位研究，证实USP46通过去泛素化PERIOD蛋白调控生物钟基因表达及昼夜节律。

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建议通过PubMed、Google Scholar等平台以“USP46 antibody”或“USP46 deubiquitinase”为关键词检索真实文献。

背景信息

The UBP46 antibody targets UBP46. a member of the ubiquitin-specific protease (USP) family, which regulates protein deubiquitination—a critical post-translational modification process. UBP46. also known as USP46 in standardized nomenclature, is implicated in modulating ubiquitin-dependent signaling pathways by removing ubiquitin moieties from substrate proteins, thereby influencing their stability, localization, or activity. This enzyme is particularly noted for its role in neuronal function and behavior, with studies linking it to synaptic plasticity, neurotransmitter receptor regulation (e.g., GABA receptors), and neuropsychiatric conditions such as depression and anxiety. UBP46/USP46 is also explored in cancer research due to its potential involvement in oncoprotein stabilization or tumor suppressor degradation. The UBP46 antibody is a key tool for detecting endogenous UBP46 expression via techniques like Western blotting, immunohistochemistry, or immunofluorescence, aiding in functional studies to elucidate its physiological and pathological roles. Its development and validation typically involve specificity checks using knockout controls or siRNA knockdowns. Research utilizing this antibody contributes to understanding deubiquitinating enzymes' broader impact on cellular homeostasis and disease mechanisms.

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