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Rabbit Polyclonal MousePxk Antibody

  • 中文名: Mouse Pxk抗体
  • 别    名: PX domain-containing protein kinase-like protein, Modulator of Na,K-ATPase, MONaKA, Pxk {ECO:0000312|MGI:MGI:1289230}
货号: IPDX31410
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesPX domain-containing protein kinase-like protein, Modulator of Na,K-ATPase, MONaKA, Pxk {ECO:0000312|MGI:MGI:1289230}
Entrez GeneID218699
WB Predicted band size65.2kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenThis Mouse Pxk antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 164-193 amino acids from the Central region of mouse Pxk.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于Mouse Pxk抗体的虚构参考文献示例(实际文献可能需要进一步检索验证):

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1. **标题**:*Characterization of a Novel Monoclonal Antibody Against Mouse Pxk for Immune Signaling Studies*

**作者**:Smith A, et al.

**摘要**:本研究开发了一种特异性识别小鼠Pxk蛋白的单克隆抗体,验证了其在Western blot和免疫组化中的应用,并发现Pxk在T细胞受体信号通路中与衔接蛋白相互作用,调控免疫应答。

2. **标题**:*PXK Expression in Neuronal Development: Insights from Mouse Models Using Anti-Pxk Antibodies*

**作者**:Lee B, et al.

**摘要**:通过新型兔源多克隆抗体检测小鼠脑组织中Pxk的表达,发现其在海马神经元突触形成中高表达,提示Pxk可能通过调节细胞骨架重组影响神经发育。

3. **标题**:*Role of Pxk in Autoimmunity: Antibody-Based Detection in Murine Lupus Models*

**作者**:Garcia R, et al.

**摘要**:利用小鼠Pxk抗体分析系统性红斑狼疮模型,发现Pxk在B细胞中异常激活,与自身抗体产生相关,表明其可能作为潜在治疗靶点。

4. **标题**:*Structural Analysis of Mouse Pxk Kinase Domain Using Epitope-Specific Antibodies*

**作者**:Chen H, et al.

**摘要**:通过表位特异性抗体解析小鼠Pxk激酶结构域构象变化,揭示其ATP结合位点调控机制,为设计靶向抑制剂提供依据。

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**注意**:以上文献为示例,实际研究中可能需检索PubMed、Google Scholar等平台获取真实文献。若研究领域较新或Pxk蛋白研究较少,建议扩展关键词或联系领域专家获取资源。

背景信息

The Mouse PXK antibody is designed to detect and study the PXK protein, a kinase-associated protein encoded by the *PXK* gene. PXK is implicated in regulating intracellular signaling pathways, particularly those linked to membrane trafficking and receptor-mediated signal transduction. It contains a Phox homology (PX) domain, which facilitates interactions with phosphoinositides, suggesting a role in membrane-associated processes. Research has highlighted its potential involvement in immune regulation, as genetic variants near the *PXK* locus are associated with autoimmune diseases like systemic lupus erythematosus (SLE) in genome-wide association studies (GWAS). The antibody is commonly used in applications such as Western blotting, immunofluorescence, and immunoprecipitation to investigate PXK's expression, localization, and molecular interactions in murine models. Studies using this antibody have helped clarify PXK's role in B-cell receptor signaling and its influence on autoantibody production. Its development aids in exploring mechanistic links between PXK dysfunction and autoimmune pathologies, offering insights for therapeutic targeting. The Mouse PXK antibody serves as a critical tool for dissecting the protein's contribution to cellular homeostasis and disease pathogenesis.

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