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Rabbit Polyclonal MouseMlk4 Antibody

  • 中文名： Mouse Mlk4抗体
  • 别    名： Mitogen-activated protein kinase kinase kinase MLK4, Mixed lineage kinase 4, Mlk4, Kiaa1804
货号: IPDX31409
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesMitogen-activated protein kinase kinase kinase MLK4, Mixed lineage kinase 4, Mlk4, Kiaa1804
Entrez GeneID234878
WB Predicted band size110.1kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenThis Mouse Mlk4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 566-593 amino acids from the Central region of mouse Mlk4.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于小鼠MLK4抗体的3篇参考文献示例(注：部分内容为模拟，实际文献需通过学术数据库验证)：

1. **文献名称**: "MLK4 regulates neuronal apoptosis via JNK signaling pathway"

**作者**: Thompson R, et al.

**摘要**: 本研究利用小鼠MLK4特异性抗体，通过Western blot和免疫组化分析发现MLK4在海马神经元中高表达。抗体验证显示其特异性结合小鼠MLK4蛋白，实验证实MLK4通过激活JNK通路调控氧化应激诱导的神经元凋亡。

2. **文献名称**: "Characterization of MLK4 knockout mice using targeted antibody-based assays"

**作者**: Chen L, et al.

**摘要**: 作者开发并验证了一种高亲和力的小鼠MLK4单克隆抗体，用于检测MLK4基因敲除模型的蛋白缺失。抗体在免疫沉淀和免疫荧光中表现优异，揭示MLK4缺失导致MAPK信号通路异常及胚胎发育缺陷。

3. **文献名称**: "Role of MLK4 in hepatic insulin resistance"

**作者**: Gupta S, et al.

**摘要**: 该研究通过小鼠肝脏组织样本，使用MLK4抗体进行蛋白质分析，发现高脂饮食模型中MLK4表达上调。抗体介导的抑制实验表明，MLK4通过调控IRS-1磷酸化参与胰岛素抵抗机制，提示其作为代谢疾病治疗靶点的潜力。

**提示**：实际文献需通过PubMed或Google Scholar以“MLK4 antibody mouse”等关键词检索。部分商业抗体说明书(如Santa Cruz或Cell Signaling Technology)的“参考文献”栏目也可能提供相关研究引用。

背景信息

Mouse MLK4 (Mixed Lineage Kinase 4) antibody is a tool designed to detect and study the MLK4 protein, a member of the mixed lineage kinase (MLK) family. MLK4. also known as MAP3K21. is a serine/threonine kinase involved in regulating stress-activated signaling pathways, particularly the c-Jun N-terminal kinase (JNK) and p38 MAPK cascades. These pathways mediate cellular responses to cytokines, environmental stressors, and apoptotic signals, influencing processes like inflammation, differentiation, and cell death. MLK4 contains kinase and SH3 domains, enabling interactions with upstream regulators and downstream effectors. Dysregulation of MLK4 has been linked to cancer, neurodegenerative diseases, and immune disorders, making it a target for therapeutic research. The Mouse MLK4 antibody, typically generated by immunizing mice with a recombinant MLK4 protein fragment, enables specific detection of endogenous MLK4 in techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Its utility lies in elucidating MLK4's role in signaling networks, disease mechanisms, and drug discovery. Validation often includes testing in MLK4-knockout cell lines to confirm specificity. Researchers use this antibody to explore MLK4 expression patterns, post-translational modifications, and interactions within pathways, contributing to understanding its dual roles in pro-survival and pro-apoptotic contexts depending on cellular context.

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