| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Sorting nexin-24, SNX24 |
| Entrez GeneID | 28966 |
| WB Predicted band size | 19.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SNX24 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 86-113 amino acids from the Central region of human SNX24. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SNX24抗体的3篇参考文献示例(注：以下内容为模拟生成，实际文献可能需要通过学术数据库查询确认)：
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1. **文献名称**: *Sorting Nexin 24 regulates neuronal morphogenesis through mediating endosomal trafficking of TrkB receptors*
**作者**: Li Y, et al.
**摘要**: 本研究利用SNX24特异性抗体，揭示了SNX24在神经元发育中的作用。通过免疫荧光和免疫共沉淀实验，发现SNX24通过与TrkB受体结合调控其内体运输，影响神经突触的形成和神经细胞极性。
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2. **文献名称**: *SNX24 modulates EGFR degradation via endosomal sorting and impacts cancer cell proliferation*
**作者**: Wang H, et al.
**摘要**: 研究通过Western blot和免疫组化使用SNX24抗体，证明SNX24通过调控表皮生长因子受体(EGFR)的内体分选过程促进其溶酶体降解，从而抑制肺癌细胞的增殖和迁移。
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3. **文献名称**: *Structural and functional characterization of SNX24 in membrane remodeling*
**作者**: Zhang R, et al.
**摘要**: 该文献利用SNX24抗体进行蛋白质定位和功能分析，发现SNX24通过其PX和BAR结构域参与细胞膜形态重塑，并揭示了其与脂质结合的能力，为理解SNX24在膜运输中的作用提供了机制依据。
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如果需要具体文献，建议通过PubMed或Google Scholar以“SNX24 antibody”或“SNX24 function”为关键词检索，并筛选涉及抗体应用的实验研究。
The SNX24 antibody is a research tool designed to detect and analyze Sorting Nexin 24 (SNX24), a member of the sorting nexin protein family. Sorting nexins are characterized by a conserved Phox homology (PX) domain, which facilitates membrane association by binding phosphatidylinositol phospholipids. SNX24 plays roles in intracellular trafficking, membrane remodeling, and protein sorting, particularly within endosomal compartments. It is implicated in regulating endosome-to-Golgi retrograde transport and may interact with components of the retromer complex, though its precise molecular mechanisms remain less defined compared to other sorting nexins like SNX1 or SNX2.
SNX24 antibodies are typically developed in hosts such as rabbits or mice using immunogenic peptides derived from SNX24’s unique regions. These antibodies enable techniques like Western blotting, immunofluorescence, and immunoprecipitation to study SNX24’s expression, localization, and interactions. Researchers utilize them to explore SNX24’s involvement in cellular processes, including autophagy, receptor recycling, and signaling pathways. Dysregulation of SNX24 has been linked to neurological disorders and cancer, making its study relevant for understanding disease mechanisms.
Validation of SNX24 antibodies often includes testing in knockout cell lines or tissues to confirm specificity. Their application supports broader investigations into the functional diversity of sorting nexins and their impact on cellular homeostasis.
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