| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Carboxypeptidase O, CPO, 3417-, CPO |
| Entrez GeneID | 130749 |
| WB Predicted band size | 42.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CPO antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-75 amino acids from the N-terminal region of human CPO. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CPO(N-terminal)抗体的3篇参考文献示例(注：文献为虚构示例，仅供参考格式)：
1. **文献名称**：*Development of a High-Affinity N-Terminal Antibody for Chloroperoxidase (CPO) in Bacterial Systems*
**作者**：Chen L, et al.
**摘要**：本研究报道了一种针对细菌来源氯过氧化物酶(CPO)N端表位的高特异性多克隆抗体的开发。通过重组表达CPO的N端肽段免疫兔，获得抗体，经ELISA和Western blot验证其对天然CPO的识别能力，并成功应用于微生物酶活性调控研究。
2. **文献名称**：*Immunodetection of Fungal CPO Using N-Terminus-Targeted Monoclonal Antibodies*
**作者**：Rodriguez M, et al.
**摘要**：研究团队制备了靶向真菌CPO蛋白N端的单克隆抗体，通过免疫组化验证其在真菌感染组织中的定位能力，为病原体检测提供了新型工具，并揭示CPO在宿主-病原体互作中的潜在作用。
3. **文献名称**：*Structural Characterization of CPO's N-Terminal Domain and Its Antibody Interaction*
**作者**：Wang X, et al.
**摘要**：结合冷冻电镜和表位映射技术，解析了CPO蛋白N端结构域的构象，并设计出可阻断酶活性的功能性抗体，为基于抗体的CPO抑制剂开发奠定基础。
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**提示**：若需真实文献，建议在PubMed或Google Scholar中检索关键词：
`"CPO N-terminal antibody"`、`"Chloroperoxidase antibody epitope"`，并筛选近年研究。
The CPO (N-term) antibody is a specific immunological tool designed to target the N-terminal region of the coproporphyrinogen oxidase (CPO) enzyme, also known as CPOX. CPO is a mitochondrial enzyme critical in the heme biosynthesis pathway, catalyzing the sixth step: the oxidative decarboxylation of coproporphyrinogen III to protoporphyrinogen IX. Mutations in the CPOX gene are linked to hereditary coproporphyria (HCP), a rare metabolic disorder characterized by acute neurovisceral symptoms and cutaneous photosensitivity. The N-terminal domain of CPO plays a role in substrate recognition and enzyme stability, making it a key region for functional studies.
This antibody is commonly used in research applications such as Western blotting, immunohistochemistry, and immunofluorescence to detect CPO expression levels, localization, and post-translational modifications. Its specificity for the N-terminal epitope ensures minimal cross-reactivity with other heme biosynthesis enzymes. Developed in host species like rabbit or mouse, it is often validated using CPOX-knockout cell lines or tissues to confirm target specificity. Studies utilizing this antibody contribute to understanding CPO's role in heme regulation, its dysfunction in porphyrias, and potential therapeutic strategies. Its reliability in detecting both endogenous and overexpressed CPO makes it valuable in both clinical and basic research contexts.
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