| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Serine/threonine-protein kinase 26, Stk26 {ECO:0000312|MGI:MGI:1917665} |
| Entrez GeneID | 70415 |
| WB Predicted band size | 46.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This Mouse Mst4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 271-299 amino acids from the Central region of mouse Mst4. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇涉及Mouse MST4抗体的文献概览：
1. **文献名称**: "MST4 kinase regulates immune cell homeostasis in the intestine"
**作者**: Smith J, et al.
**摘要**: 研究使用小鼠MST4抗体进行Western blot分析，发现MST4通过调控T细胞信号通路维持肠道免疫稳态，基因敲除导致肠道炎症加剧。
2. **文献名称**: "Role of MST4 in neuronal polarization and axon outgrowth"
**作者**: Chen L, et al.
**摘要**: 通过免疫荧光(小鼠MST4抗体)证明MST4激酶在神经元极性建立中的作用，抑制MST4导致轴突导向缺陷。
3. **文献名称**: "MST4 modulates hepatic lipid metabolism via AMPK pathway"
**作者**: Wang Y, et al.
**摘要**: 采用MST4抗体检测小鼠肝脏组织，发现MST4缺失通过AMPK通路促进脂质堆积，提示其与代谢性疾病相关。
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**注**：以上为模拟文献，实际文献需通过PubMed/Google Scholar检索关键词“Mouse MST4 antibody”、“MST4 kinase immune”等获取。若需具体文献，可提供数据库访问权限进一步查询。
The mammalian STE20-like protein kinase 4 (MST4), also known as STK26. is a serine/threonine kinase belonging to the germinal center kinase (GCK) subfamily within the STE20 kinase superfamily. It plays critical roles in regulating cell proliferation, apoptosis, polarity, and migration by phosphorylating downstream targets involved in signaling pathways such as the Hippo pathway and stress-response cascades. MST4 is ubiquitously expressed, with notable activity in tissues like the liver, brain, and immune cells, and has been implicated in cancer progression, metabolic regulation, and inflammatory responses.
Mouse MST4 antibodies are essential tools for studying its expression, localization, and function in cellular and disease models. These antibodies are typically produced by immunizing hosts (e.g., rabbits or mice) with purified recombinant MST4 protein or specific peptide sequences. They enable detection of endogenous MST4 via techniques like Western blotting, immunofluorescence, and immunohistochemistry. Some antibodies specifically recognize phosphorylated forms, aiding in the analysis of MST4 activation states. Research using these antibodies has highlighted MST4's role in regulating cell polarity through interactions with STRADα/MO25 and the ERM (ezrin-radixin-moesin) proteins, as well as its crosstalk with AMPK and mTOR pathways in metabolic stress adaptation. Validated MST4 antibodies are crucial for exploring its dual roles as a tumor suppressor or promoter, depending on cellular context.
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