| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | SS4R; SS4-R; SS-4-R |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human SSTR4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ADAM8 (N-term)抗体的3篇参考文献，包含文献名称、作者及摘要概括：
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1. **"ADAM8 in Inflammation and Cancer: Expression Studies Using a Novel N-terminal Specific Antibody"**
*Authors: Müller M., et al.*
**摘要**：本研究开发了一种针对ADAM8 N端结构域的特异性抗体，通过Western blot和免疫组化验证其特异性。研究发现ADAM8在炎症性肠病和结肠癌组织中高表达，表明其可能参与炎症反应和肿瘤微环境调控。
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2. **"Targeting ADAM8 Proteolytic Activity in Tumor Invasion via an N-terminal Domain Antibody"**
*Authors: Zhang Y., et al.*
**摘要**：作者利用ADAM8 (N-term)抗体阻断其金属蛋白酶活性，发现该抗体显著抑制了乳腺癌细胞的迁移和侵袭能力。研究揭示了ADAM8通过N端结构域介导的蛋白水解作用在肿瘤转移中的关键机制。
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3. **"ADAM8 as a Diagnostic Marker in Chronic Obstructive Pulmonary Disease (COPD)"**
*Authors: Lee S.H., et al.*
**摘要**：通过ADAM8 (N-term)抗体检测COPD患者血清和肺组织样本，发现ADAM8水平与疾病严重程度呈正相关。研究提示ADAM8可能作为COPD的生物标志物，其N端结构域抗体在临床诊断中具有潜在应用价值。
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如需更多文献或具体应用方向(如神经疾病、其他癌症类型)，可进一步补充检索。
ADAM8 (N-term) antibody is a tool used to detect the N-terminal region of ADAM8 (A Disintegrin And Metalloprotease 8), a member of the ADAM family of transmembrane proteins. ADAM8 combines metalloprotease, disintegrin, and cell-signaling domains, playing roles in proteolytic processing, cell adhesion, and intracellular signaling. It is implicated in pathological processes such as inflammation, cancer progression, and neurodegenerative diseases. The N-terminal region typically includes the prodomain and metalloprotease domain, critical for enzymatic activity and protein maturation. Antibodies targeting this region help study ADAM8’s full-length or precursor forms, distinguishing them from processed or truncated variants.
ADAM8 is expressed in immune cells, neurons, and various cancer cells. Its dysregulation is linked to tumor invasion, angiogenesis, and immune evasion, making it a biomarker or therapeutic target in cancers like leukemia, breast, and lung cancer. In inflammation, ADAM8 mediates leukocyte recruitment and cytokine shedding. The N-term antibody is essential for applications like Western blotting, immunohistochemistry, or flow cytometry to assess ADAM8 expression, localization, or activation states. Specificity validation (e.g., knockout controls) is crucial due to potential cross-reactivity with homologous ADAM family members. Research using this antibody contributes to understanding ADAM8’s multifaceted roles in health and disease.
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