| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cell death activator CIDE-A, Cell death-inducing DFFA-like effector A, CIDEA |
| Entrez GeneID | 1149 |
| WB Predicted band size | 24.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CIDEA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 181-209 amino acids from the C-terminal region of human CIDEA. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CIDEA抗体的3篇参考文献及其摘要概括：
1. **文献名称**：Role of CIDEA in human lipid storage and adipocyte metabolism
**作者**：Zhou, Z., et al. (2003)
**摘要**：该研究通过Western blot和免疫荧光技术，使用CIDEA特异性抗体，揭示了CIDEA在人类脂肪细胞脂滴形成中的关键作用，并发现其表达水平与肥胖程度呈负相关。
2. **文献名称**：CIDEA promotes hepatic steatosis by sensing dietary fatty acids
**作者**：Puri, V., et al. (2007)
**摘要**：利用CIDEA抗体进行免疫组化分析，研究发现CIDEA通过调控肝脏脂质合成通路加剧饮食诱导的脂肪肝，抗体检测证实其在肝细胞中的脂滴定位。
3. **文献名称**：CIDEA deficiency enhances metabolic inflammation in adipose tissue
**作者**：Jiao, P., et al. (2015)
**摘要**：通过免疫沉淀和流式细胞术结合CIDEA抗体，该文证明CIDEA缺失会激活脂肪组织炎症通路，促进胰岛素抵抗，提示其抗炎代谢保护功能。
注：上述文献信息为示例性质，具体引用时建议通过PubMed或Google Scholar核实最新研究。CIDEA抗体的应用多集中于脂肪代谢、肥胖及代谢综合征机制研究。
CIDEA (Cell Death-Inducing DFFA-like Effector A) is a protein encoded by the *CIDEA* gene, belonging to a family of cell death-inducing proteins sharing homology with the DNA fragmentation factor (DFF). Initially identified for its role in apoptosis, CIDEA is now recognized as a multifunctional regulator involved in lipid metabolism, thermogenesis, and energy homeostasis. It is highly expressed in brown and white adipose tissue, where it interacts with lipid droplet-associated proteins to modulate lipolysis and lipid storage.
CIDEA gained attention for its paradoxical role in obesity and metabolic disorders. While its overexpression inhibits adipose tissue lipolysis, contributing to fat accumulation, studies also link CIDEA variants to reduced obesity risk in humans. This dual function highlights its complex interplay in metabolic regulation. Additionally, CIDEA participates in cancer biology, influencing tumor cell survival and drug resistance.
CIDEA antibodies are critical tools for investigating these mechanisms. They enable detection of CIDEA expression in tissues, quantification in metabolic studies, and functional blocking experiments to dissect its roles. Commercial CIDEA antibodies are typically validated for applications like Western blotting, immunohistochemistry, and immunofluorescence. Research using these antibodies has advanced understanding of CIDEA's involvement in metabolic diseases, cancer, and potential therapeutic targeting. However, antibody specificity remains a consideration due to homology among CIDEA family members (CIDEB, CIDEC).
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