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Rabbit Polyclonal STAM2 Antibody

  • 中文名： STAM2抗体
  • 别    名： Signal transducing adapter molecule 2, STAM-2, Hrs-binding protein, STAM2, HBP
货号: IPDX31388
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesSignal transducing adapter molecule 2, STAM-2, Hrs-binding protein, STAM2, HBP
Entrez GeneID10254
WB Predicted band size58.2kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis STAM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 143-172 amino acids from the Central region of human STAM2.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是3篇关于STAM2抗体的虚构参考文献示例(内容为模拟概括，非真实文献)：

1. **文献名称**：*STAM2 regulates endosomal sorting of EGFR through ESCRT-I interaction*

**作者**：T. Kobayashi et al.

**摘要**：研究揭示了STAM2通过其VHS结构域与ESCRT-I复合物结合，调控表皮生长因子受体(EGFR)的内体分选及溶酶体降解。该研究利用特异性STAM2抗体验证了其在泛素化信号传递中的关键作用。

2. **文献名称**：*Structural basis of STAM2-mediated signal transduction in immune cells*

**作者**：M. Chen & R. Gupta

**摘要**：通过免疫共沉淀和冷冻电镜技术，解析了STAM2与Hrs蛋白形成的复合物结构，阐明其参与TLR信号通路的机制。研究使用STAM2抗体阻断实验证实其对NF-κB激活的调控功能。

3. **文献名称**：*STAM2 deficiency exacerbates neurodegeneration via impaired autophagy*

**作者**：L. Wang et al.

**摘要**：在帕金森病模型中，STAM2敲除导致自噬体成熟障碍，加剧α-synuclein聚集。通过STAM2抗体标记发现其在小胶质细胞中高表达，提示其在神经炎症中的潜在作用。

4. **文献名称**：*Development of a high-affinity monoclonal antibody for STAM2 functional studies*

**作者**：S. Patel et al.

**摘要**：报道了一种新型STAM2单克隆抗体的开发，该抗体可特异性识别STAM2的SH3结构域，应用于流式细胞术和免疫荧光，为研究STAM2在癌症转移中的功能提供了工具。

(注：以上文献为虚构，仅用于示例格式及内容框架)

背景信息

The STAM2 (Signal Transducing Adaptor Molecule 2) antibody is a tool used to detect and study the STAM2 protein, a key component in intracellular signaling pathways. STAM2. part of the STAM family (STAM1 and STAM2), functions as an adaptor protein involved in cell signaling regulation, particularly in cytokine-mediated pathways and receptor tyrosine kinase signaling. It contains multiple domains, including a VHS (Vps27/Hrs/STAM) domain, SH3 (Src homology 3) domain, and ITAM (Immunoreceptor Tyrosine-based Activation Motif), enabling interactions with ubiquitinated proteins and other signaling molecules. STAM2 plays a role in endosomal sorting, lysosomal trafficking, and signal transduction, often partnering with Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) to form the ESCRT-0 complex, which mediates cargo sorting into multivesicular bodies (MVBs). Dysregulation of STAM2 is implicated in cancer, immune disorders, and neurodegenerative diseases. Researchers use STAM2 antibodies in techniques like Western blotting, immunoprecipitation, and immunofluorescence to investigate its expression, localization, and interactions in cellular processes. These antibodies are critical for elucidating STAM2's role in EGFR degradation, JAK-STAT signaling, and autophagy, providing insights into disease mechanisms and therapeutic targets. Species reactivity typically includes human, mouse, and rat samples, with validation via knockout controls ensuring specificity.

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