| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, PP2A B subunit isoform B'-gamma, PP2A B subunit isoform B56-gamma, PP2A B subunit isoform PR61-gamma, PP2A B subunit isoform R5-gamma, Renal carcinoma antigen NY-REN-29, PPP2R5C, KIAA0044 |
| Entrez GeneID | 5527 |
| WB Predicted band size | 61.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PPP2R5C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 465-494 amino acids from the C-terminal region of human PPP2R5C. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PPP2R5C抗体的3篇参考文献及其简要摘要：
1. **文献名称**: *"Characterization of a monoclonal antibody specific for the B56γ3 regulatory subunit of PP2A"*
**作者**: Chen et al. (2015)
**摘要**: 本研究开发了一种针对PPP2R5C/B56γ3亚型特异性单克隆抗体，验证了其在免疫印迹和免疫沉淀中的高特异性，并应用于探究该亚型在细胞周期调控中的作用。
2. **文献名称**: *"PP2A-B56γ antibody reveals dynamic subcellular localization in neuronal development"*
**作者**: Smith et al. (2018)
**摘要**: 文章利用商业化PPP2R5C抗体，通过免疫荧光技术揭示了B56γ在神经元突触形成中的动态定位，提示其参与神经发育的信号通路调控。
3. **文献名称**: *"Validation of phospho-specific antibodies targeting PP2A-B56γ in cancer signaling studies"*
**作者**: Lee & Johnson (2020)
**摘要**: 研究验证了多种磷酸化位点特异性PPP2R5C抗体的可靠性，证明其在乳腺癌模型中对AKT/mTOR通路中PP2A功能研究的关键作用。
4. **文献名称**: *"Antibody-based profiling of B56γ isoforms in human tissues"*
**作者**: Müller et al. (2019)
**摘要**: 通过多克隆抗体分析PPP2R5C不同剪接变体在正常与肿瘤组织中的表达差异，发现B56γ2亚型在结肠癌中显著上调，提示其临床相关性。
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**备注**：以上文献信息为示例性内容，实际文献需通过PubMed或Web of Science以关键词“PPP2R5C antibody”“B56γ antibody”等检索确认。
The PPP2R5C antibody targets the protein phosphatase 2 regulatory subunit B56γ, a component of the heterotrimeric Protein Phosphatase 2A (PP2A) complex. PP2A is a serine/threonine phosphatase critical for regulating diverse cellular processes, including cell cycle progression, signal transduction, and apoptosis. The B56γ subunit, encoded by PPP2R5C, modulates PP2A substrate specificity, enzymatic activity, and subcellular localization, often determining the complex's functional role in specific pathways. Dysregulation of PP2A-B56γ has been implicated in cancers, neurodegenerative disorders, and metabolic diseases, making it a focus of therapeutic research.
Antibodies against PPP2R5C are widely used in biomedical research to study PP2A complex assembly, post-translational modifications, and interactions with signaling molecules like AKT, Wnt, and p53. They enable detection of B56γ expression levels via techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Additionally, these antibodies aid in exploring PPP2R5C's role in cellular responses to stress, DNA damage, and oncogenic signaling. Commercially available PPP2R5C antibodies are typically raised in rabbits or mice, with validation in knockout cell lines or tissues to confirm specificity. Their application extends to clinical studies, where altered PPP2R5C expression serves as a biomarker for disease progression or therapeutic targeting.
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