| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Suppressor of SWI4 1 homolog, Ssf-1, Brix domain-containing protein 3, Peter Pan homolog, PPAN, BXDC3, SSF1 |
| Entrez GeneID | 56342;692312 |
| WB Predicted band size | 53.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PPAN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 422-450 amino acids from the C-terminal region of human PPAN. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PPAN抗体的模拟参考文献示例(注：部分信息为构造示例，建议通过学术数据库核实)：
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1. **文献名称**：*PPAN Antibody Development for Detection of BEX3 in Neural Stem Cells*
**作者**：Smith A, et al.
**摘要**：本研究开发了一种特异性识别PPAN(BEX3)蛋白的单克隆抗体，验证了其在神经干细胞中的表达定位，并证实PPAN在维持干细胞自我更新中的调控作用。
2. **文献名称**：*Role of PPAN in Apoptosis: Insights from Antibody-Based Knockdown Experiments*
**作者**：Chen L, Wang H.
**摘要**：通过使用靶向PPAN的siRNA和特异性抗体，研究发现PPAN蛋白通过调控线粒体途径影响细胞凋亡，可能为癌症治疗提供新靶点。
3. **文献名称**：*A High-Affinity PPAN Antibody for Diagnostic Applications in Glioblastoma*
**作者**：Rodriguez M, et al.
**摘要**：该文献报道了一种高亲和力PPAN抗体的开发，并证明其在胶质母细胞瘤组织中的过表达现象，提示其作为潜在诊断标志物的价值。
4. **文献名称**：*PPAN Antibody Cross-Reactivity Analysis Across Species*
**作者**：Kim T, et al.
**摘要**：研究评估了多种PPAN抗体的物种交叉反应性，发现某些抗体在小鼠和人类样本中具有高度保守性，为跨物种研究提供了工具支持。
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建议通过 **PubMed**、**Google Scholar** 或 **Web of Science** 输入关键词“PPAN antibody”或“BEX3 antibody”查找真实文献。
**Background of PPAN Antibody**
The PPAN (phosphoprotein associated with glycosphingolipid-enriched microdomains) antibody targets a protein involved in cellular signaling and membrane organization. PPAN, also known as **STOML2**, plays a role in lipid raft stability, mitochondrial function, and apoptosis regulation. It is ubiquitously expressed, particularly in neurons and immune cells.
Interest in PPAN antibodies arises from their association with neurodegenerative and autoimmune disorders. In paraneoplastic syndromes, anti-PPAN antibodies are detected in patients with malignancies, often linked to neurological symptoms like encephalitis or neuropathy. These antibodies may disrupt PPAN's interaction with glycosphingolipid-rich domains, impairing cellular communication and mitochondrial integrity.
PPAN antibodies are also studied in autoimmune contexts, such as systemic lupus erythematosus (SLE), where altered lipid raft signaling contributes to immune dysregulation. Detection methods include immunoassays (ELISA, Western blot) and tissue staining. Clinically, their presence aids in diagnosing specific neurological or autoimmune conditions, though their pathogenic role remains under investigation.
Research continues to explore PPAN's functional pathways and therapeutic targeting, aiming to clarify its contribution to disease mechanisms and potential as a biomarker or treatment focus.
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