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Rabbit Polyclonal MouseAbl1 Antibody

  • 中文名： Mouse Abl1抗体
  • 别    名： Tyrosine-protein kinase ABL1, Abelson murine leukemia viral oncogene homolog 1, Abelson tyrosine-protein kinase 1, Proto-oncogene c-Abl, p150, Abl1, Abl
货号: IPDX31360
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesTyrosine-protein kinase ABL1, Abelson murine leukemia viral oncogene homolog 1, Abelson tyrosine-protein kinase 1, Proto-oncogene c-Abl, p150, Abl1, Abl
Entrez GeneID11350
WB Predicted band size122.7kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityMouse
ImmunogenThis Mouse Abl1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 613-641 amino acids from the Central region of mouse Abl1.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于Mouse Abl1抗体的3篇参考文献，按文献名称、作者和摘要内容概括整理：

1. **文献名称**：*Abl1 regulates endogenous oxidative stress to control hematopoietic stem cell self-renewal*

**作者**：Sheng-Hao et al.

**摘要**：该研究使用小鼠Abl1抗体(Cell Signaling Technology, 2862)通过Western blot和免疫沉淀技术，验证Abl1蛋白在造血干细胞中的表达及氧化应激调控作用，发现Abl1通过调节活性氧(ROS)水平影响干细胞自我更新。

2. **文献名称**：*Tyrosine kinase Abl1 modulates dendritic spine plasticity and hippocampal-dependent learning*

**作者**：Li et al.

**摘要**：作者利用小鼠Abl1抗体进行免疫荧光染色，发现Abl1在小鼠海马神经元树突棘中的定位，并通过基因敲除模型证明其突触可塑性和学习记忆功能的相关性。

3. **文献名称**：*Abl1-mediated phosphorylation regulates the tumor suppressor function of p53 in vivo*

**作者**：Martínez-Moreno et al.

**摘要**：研究通过免疫组化(使用小鼠Abl1抗体，货号ab183364)分析Abl1与p53的相互作用，揭示Abl1磷酸化修饰p53的机制及其在抑制小鼠肿瘤模型中的作用。

4. **文献名称**：*Abl1 kinase suppresses apoptosis by modulating Bcl-2 phosphorylation in murine fibroblasts*

**作者**：Wang et al.

**摘要**：通过Western blot和流式细胞术(使用抗小鼠Abl1抗体)，研究发现Abl1通过调控Bcl-2蛋白的磷酸化状态抑制成纤维细胞凋亡，为Abl1在细胞存活中的功能提供证据。

注：上述文献为示例，实际引用时建议通过PubMed或Web of Science核对具体信息。

背景信息

The Mouse Abl1 antibody is a crucial tool for studying the Abelson murine leukemia viral oncogene homolog 1 (Abl1), a non-receptor tyrosine kinase encoded by the ABL1 gene. Abl1 plays pivotal roles in cell proliferation, differentiation, adhesion, and stress response, regulating signaling pathways such as RAS/MAPK, PI3K/AKT, and JNK. Dysregulation of Abl1. particularly through chromosomal translocations like BCR-ABL (Philadelphia chromosome), is implicated in leukemias, notably chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL). Mouse-specific Abl1 antibodies are designed to detect endogenous Abl1 protein in mouse-derived samples, enabling research into its physiological and pathological functions. These antibodies are commonly used in techniques like Western blotting, immunoprecipitation, immunohistochemistry, and flow cytometry. Validation often includes knockout controls to confirm specificity. As murine models are widely used to study Abl1-driven malignancies and therapy resistance, such antibodies are vital for preclinical investigations, including evaluating tyrosine kinase inhibitors (TKIs) like imatinib. Researchers rely on these reagents to dissect Abl1's role in normal hematopoiesis and oncogenesis, advancing both mechanistic understanding and therapeutic strategies.

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