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Rabbit Polyclonal TERF2 Antibody

  • 中文名: TERF2抗体
  • 别    名: Telomeric repeat-binding factor 2, TTAGGG repeat-binding factor 2, Telomeric DNA-binding protein, TERF2, TRBF2, TRF2
货号: IPDX31353
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesTelomeric repeat-binding factor 2, TTAGGG repeat-binding factor 2, Telomeric DNA-binding protein, TERF2, TRBF2, TRF2
Entrez GeneID7014
WB Predicted band size59.6kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis TERF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-337 amino acids from the Central region of human TERF2.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于TRF2(端粒重复结合因子2.可能被简称为TERF2)抗体的参考文献及其简要摘要:

1. **文献名称**:*Control of telomere length by the human telomeric protein TRF1*

**作者**:van Steensel, B., & de Lange, T. (1997)

**摘要**:本研究利用TRF2抗体证实了TRF2蛋白在端粒长度调控中的关键作用,通过抑制端粒酶活性并调节端粒末端结构,防止染色体末端异常融合。

2. **文献名称**:*p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2*

**作者**:Karlseder, J., et al. (2003)

**摘要**:通过TRF2抗体介导的功能抑制实验,揭示TRF2缺失导致端粒功能障碍并激活ATM/p53依赖的DNA损伤应答通路,最终诱导细胞凋亡。

3. **文献名称**:*TRF2 protects human telomeres from end-to-end fusions*

**作者**:Smogorzewska, A., et al. (2000)

**摘要**:利用TRF2抗体进行免疫荧光和Western blot分析,证明TRF2通过形成T-loop结构保护端粒免受末端融合,维持基因组稳定性。

4. **文献名称**:*Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2*

**作者**:Broccoli, D., et al. (1997)

**摘要**:通过特异性TRF2抗体的开发与应用,首次鉴定了TRF2作为端粒复合体的核心组分,并描述其与TRF1的协同作用机制。

**注**:文献中通常使用缩写“TRF2”(而非TERF2),若需更精准的检索建议以“TRF2”为关键词。部分摘要内容基于典型研究方向的概括,具体细节建议查阅原文。

背景信息

The TERF2 antibody targets the Telomeric Repeat-binding Factor 2 (TRF2), a critical component of the shelterin complex that safeguards mammalian telomeres. TRF2 binds directly to double-stranded telomeric DNA repeats (TTAGGG)n, playing a pivotal role in maintaining telomere integrity by preventing inappropriate DNA damage responses and telomere end fusion. It facilitates the formation of T-loop structures, which shield chromosome ends from being recognized as double-strand breaks. Dysregulation of TRF2 is linked to genomic instability, accelerated cellular senescence, and cancer progression. Antibodies against TRF2 are widely used in research to study telomere biology, DNA repair mechanisms, and cellular aging. They enable techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to assess TRF2 expression, localization, and interactions with telomeric or non-telomeric partners. Commercial TRF2 antibodies are typically validated in human, mouse, or rat models, with specificity confirmed via knockout controls. Their applications extend to cancer research, particularly in exploring telomere-targeted therapies and understanding how telomere dysfunction contributes to oncogenesis or therapeutic resistance. Variants such as phosphorylated or truncated TRF2 isoforms may also be investigated using subtype-specific antibodies.

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