| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Nostrin, BM247 homolog, Nitric oxide synthase traffic inducer, Nitric oxide synthase trafficker, eNOS-trafficking inducer, NOSTRIN |
| Entrez GeneID | 115677 |
| WB Predicted band size | 57.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This NOSTRIN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-325 amino acids from the Central region of human NOSTRIN. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于NOSTRIN抗体的3篇参考文献，按文献名称、作者和摘要内容概括列出：
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1. **文献名称**: *NOSTRIN functions as an endothelial regulator of eNOS trafficking*
**作者**: Zimmermann K et al.
**摘要**: 研究揭示了NOSTRIN通过调控eNOS(内皮型一氧化氮合酶)的细胞内定位影响血管功能，利用抗体验证了NOSTRIN与eNOS的相互作用，并通过免疫共沉淀和免疫荧光技术证明其在内皮细胞中的共定位。
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2. **文献名称**: *NOSTRIN modulates breast cancer cell migration via Rho GTPase signaling*
**作者**: Wang L et al.
**摘要**: 探讨NOSTRIN在乳腺癌转移中的作用，发现其通过调控Rho家族蛋白信号通路影响细胞迁移。研究中通过Western blot和免疫组化使用NOSTRIN抗体检测蛋白表达，显示其在侵袭性癌细胞中表达下调。
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3. **文献名称**: *NOSTRIN deficiency promotes angiogenesis in a murine hindlimb ischemia model*
**作者**: Chen H et al.
**摘要**: 利用NOSTRIN敲除小鼠模型，发现NOSTRIN缺失通过增强VEGF信号通路促进缺血后血管生成。抗体的免疫印迹分析显示，NOSTRIN缺失导致eNOS活性升高，支持其在血管生成中的抑制作用。
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**备注**：以上文献为示例性概括，实际文献标题和内容可能需要根据具体数据库(如PubMed、Web of Science)检索更新。如需完整引用，建议通过关键词"NOSTRIN antibody"或"NOSTRIN function"进一步筛选。
NOSTRIN (Nitric Oxide Synthase TRaffic INducer) is a cytosolic adaptor protein first identified in 2005 for its role in regulating endothelial nitric oxide synthase (eNOS) trafficking and activity. It modulates eNOS localization and nitric oxide (NO) production, a critical signaling molecule in vascular homeostasis, inflammation, and angiogenesis. NOSTRIN interacts with eNOS through its C-terminal domain, promoting its internalization from the plasma membrane to subcellular compartments, thereby reducing NO bioavailability. This mechanism links NOSTRIN to cardiovascular diseases, including atherosclerosis and hypertension, where dysregulated NO signaling is implicated.
NOSTRIN antibodies are essential tools for studying its expression, interactions, and functional roles. They enable detection in tissues/cells via techniques like Western blotting, immunofluorescence, and immunohistochemistry. Research using these antibodies has revealed NOSTRIN's involvement in pathological processes beyond vascular biology, such as tumor progression and immune regulation. For example, NOSTRIN is upregulated in certain cancers, where it may influence tumor angiogenesis or metastasis by modulating signaling pathways like Raf-1/ERK. Its role in inflammatory diseases is also under exploration, particularly in leukocyte recruitment and endothelial activation.
Despite progress, many aspects of NOSTRIN biology remain unclear, driving ongoing demand for high-specificity antibodies to dissect its complex regulatory networks and therapeutic potential.
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