| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Casein kinase II subunit alpha', CK II alpha', Csnk2a2 |
| Entrez GeneID | 13000 |
| WB Predicted band size | 41.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This Mouse Csnk2a2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-32 amino acids from the N-terminal region of mouse Csnk2a2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Mouse Csnk2a2 (N-term)抗体的3篇参考文献示例(注：文献信息为模拟，实际引用需核实)：
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1. **"Characterization of CK2α’ subunit monoclonal antibodies in murine models"**
*Authors: Smith A, et al.*
**摘要**：本研究开发并验证了针对小鼠Csnk2a2(CK2α’)N端的单克隆抗体，通过Western blot和免疫组化证实其特异性，并应用于探究CK2α’在肝癌模型中的表达调控。
2. **"CK2α’-dependent signaling in mouse neuronal development"**
*Authors: Lee H, et al.*
**摘要**：利用针对Csnk2a2 N端抗体进行免疫沉淀，揭示CK2α’在小鼠神经元分化中的关键作用，并发现其与β亚基的互作机制。
3. **"Tissue-specific expression profiling of CK2 subunits in mice"**
*Authors: Gonzalez R, et al.*
**摘要**：通过N端特异性抗体分析Csnk2a2在小鼠多种组织中的表达差异，发现其在心脏和肾脏中高表达，提示亚基功能分化。
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如需真实文献，建议通过PubMed或抗体供应商(如Thermo Fisher、Abcam)的产品引用列表查询。
The Mouse Csnk2a2 (N-term) antibody is designed to specifically target the N-terminal region of the Casein Kinase 2 Alpha Prime (Csnk2a2) protein, a catalytic subunit of the Casein Kinase 2 (CK2) serine/threonine kinase complex. CK2 is a ubiquitously expressed, evolutionarily conserved kinase involved in diverse cellular processes, including cell proliferation, apoptosis, DNA repair, and signal transduction. The CK2 holoenzyme typically exists as a tetramer composed of two catalytic subunits (α or α', encoded by Csnk2a1 and Csnk2a2. respectively) and two regulatory β subunits. While Csnk2a1 (α) and Csnk2a2 (α') share high sequence homology, they exhibit distinct expression patterns and may have partially non-redundant roles. Csnk2a2 is particularly noted for its expression in the brain and germ cells, though its functions remain less characterized compared to Csnk2a1.
The N-term antibody is crucial for distinguishing Csnk2a2 from Csnk2a1. as it targets unique epitopes within the N-terminal domain, enabling precise detection in techniques like Western blotting, immunohistochemistry, or immunoprecipitation. Researchers use this antibody to study tissue-specific CK2 activity, isoform-specific signaling mechanisms, or pathological conditions linked to CK2 dysregulation, such as cancer or neurodegenerative diseases. Its validation often includes knockout controls to confirm specificity, given the high similarity between α and α' subunits. This tool has advanced understanding of CK2's role in cellular homeostasis and disease, particularly in contexts where Csnk2a2 has unique regulatory or functional attributes.
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