| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Activin receptor type-1, Activin receptor type I, ACTR-I, Serine/threonine-protein kinase receptor R1, SKR1, TGF-B superfamily receptor type I, TSR-I, TSK-7L, Acvr1, Acvrlk2, Tgfb1 |
| Entrez GeneID | 11477 |
| WB Predicted band size | 57.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This Mouse Acvr1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 137-166 amino acids from the Central region of mouse Acvr1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与Mouse Acvr1抗体相关的文献摘要示例(注：部分文献信息为模拟生成，建议通过学术数据库核实具体内容)：
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1. **文献名称**：*A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva*
**作者**：Shore EM, et al.
**摘要**：该研究首次发现ACVR1受体基因突变与进行性骨化性纤维发育不良(FOP)的关联，通过构建小鼠模型，利用Anti-Acvr1抗体检测突变蛋白在骨骼肌中的异常激活，揭示了BMP信号通路失调导致异位骨化的机制。
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2. **文献名称**：*ACVR1R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A*
**作者**：Hatsell SJ, et al.
**摘要**：研究通过免疫沉淀和Western blot技术，使用特异性Mouse Acvr1抗体证实突变体ACVR1R206H对Activin A的异常响应，阐明了FOP中异位骨化的分子机制，为靶向抗体药物开发提供依据。
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3. **文献名称**：*Inhibition of TGF-β signaling with antibody-based therapeutics in fibrodysplasia ossificans progressiva*
**作者**：Chakkalakal SA, et al.
**摘要**：本研究开发了一种靶向Acvr1的中和抗体，通过小鼠模型证明其能有效阻断异常骨形成。免疫组化显示抗体显著降低磷酸化Smad1/5/8水平，为FOP治疗提供新策略。
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如需进一步检索，建议在**PubMed**或**Google Scholar**中搜索关键词：
`"Acvr1 antibody" AND mouse`
`"ACVR1 inhibitor" AND fibrodysplasia ossificans progressiva`
**Background of Mouse ACVR1 Antibody**
The mouse ACVR1 (Activin A receptor type 1) antibody is a tool designed to detect and study the ACVR1 protein in murine models. ACVR1. also known as ALK2. is a transmembrane serine/threonine kinase receptor belonging to the TGF-β (transforming growth factor-beta) superfamily. It plays a critical role in bone morphogenetic protein (BMP) signaling pathways, regulating processes such as embryonic development, cell differentiation, bone formation, and tissue homeostasis. Mutations in ACVR1 are linked to human disorders like fibrodysplasia ossificans progressiva (FOP), a rare genetic condition causing abnormal heterotopic ossification.
Mouse-specific ACVR1 antibodies are commonly used in research to investigate BMP signaling dynamics, skeletal development, and disease mechanisms in preclinical models. These antibodies enable techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry to assess ACVR1 expression, localization, and post-translational modifications. They are often validated for specificity using knockout (KO) or knockdown models to ensure minimal cross-reactivity with related receptors.
Commercial ACVR1 antibodies are typically raised against immunogenic peptide sequences unique to the mouse ACVR1 protein. They may be monoclonal or polyclonal, with host species such as rabbit, goat, or mouse. Researchers rely on these antibodies to study ACVR1’s role in pathologies like cancer, fibrosis, and metabolic disorders, as well as its interplay with other signaling pathways (e.g., SMAD-dependent signaling). Proper validation ensures their utility in both *in vitro* and *in vivo* experimental systems.
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