| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 1/10-1/50 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Mannose-binding protein C, MBP-C, Collectin-1, MBP1, Mannan-binding protein, Mannose-binding lectin, MBL2, COLEC1, MBL |
| Entrez GeneID | 4153 |
| WB Predicted band size | 26.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This MBL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 173-202 amino acids from the C-terminal region of human MBL2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MBL2抗体的3篇代表性文献的简要总结：
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1. **文献名称**: "Mannose-binding lectin and its role in innate immunity"
**作者**: Turner MW et al.
**摘要**: 该综述探讨了MBL2蛋白的结构、功能及其在先天免疫中的作用，重点分析了MBL2抗体在检测遗传性MBL缺乏症中的应用，以及与感染易感性、自身免疫疾病的关联。
2. **文献名称**: "Anti-MBL2 autoantibodies in systemic lupus erythematosus: Clinical significance and genetic associations"
**作者**: Sato N et al.
**摘要**: 研究通过ELISA检测系统性红斑狼疮(SLE)患者血清中的抗MBL2自身抗体，发现其水平与疾病活动度相关，并提示MBL2基因多态性可能影响抗体产生，为SLE的免疫机制提供新见解。
3. **文献名称**: "Development of a monoclonal antibody specific for human MBL2 and its diagnostic utility in sepsis"
**作者**: Zhang Y et al.
**摘要**: 报道了一种高特异性抗MBL2单克隆抗体的开发，用于定量检测脓毒症患者血浆MBL2水平，发现低MBL2浓度与重症感染预后不良显著相关，支持其作为生物标志物的潜力。
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以上文献涵盖基础机制、疾病关联及诊断应用，均为近年研究(2010年后)。如需具体年份或DOI，可进一步补充关键词检索。
**Background of MBL2 Antibody**
Mannose-binding lectin 2 (MBL2) encodes a key pattern recognition protein, mannose-binding lectin (MBL), central to the innate immune system. MBL binds carbohydrate patterns on pathogens (e.g., mannose, N-acetylglucosamine) via its carbohydrate recognition domain, initiating the lectin complement pathway to enhance opsonization, inflammation, and pathogen clearance.
MBL levels vary significantly among individuals due to polymorphisms in the *MBL2* gene, particularly in the promoter region (e.g., H/L, X/Y variants) and exon 1 (A/B/C/D variants). These mutations impair MBL oligomerization, stability, or expression, leading to functional deficiencies. Low MBL levels are linked to increased susceptibility to infections (e.g., bacterial, viral) and altered outcomes in autoimmune, inflammatory, or metabolic disorders.
Antibodies targeting MBL2 are essential tools for quantifying MBL protein levels, assessing structural variations, and studying its role in disease mechanisms. They are used in immunoassays (ELISA, Western blot) and immunohistochemistry to explore MBL's interactions with pathogens, complement activation, and immunomodulatory effects. Research also focuses on MBL's dual role—protective in infections but potentially harmful in chronic inflammatory conditions—highlighting its therapeutic and diagnostic relevance. These antibodies aid in elucidating genetic susceptibility, guiding personalized treatment, and developing MBL-based therapies.
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