| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 1/10-1/50 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Collagenase 3, 3424-, Matrix metalloproteinase-13, MMP-13, MMP13 |
| Entrez GeneID | 4322 |
| WB Predicted band size | 53.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This MMP13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 253-282 amino acids from the Central region of human MMP13. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于MMP13抗体的代表性文献，涵盖其在不同研究中的应用和功能验证：
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1. **文献名称**: *"A highly specific monoclonal antibody for MMP13 inhibits tumor growth and metastasis"*
**作者**: Li J, et al.
**摘要**: 该研究开发了一种针对MMP13的高特异性单克隆抗体，并通过体外和体内实验证明其能有效抑制肿瘤细胞的侵袭和转移。在小鼠模型中，该抗体显著降低了肿瘤生长和肺转移的发生率，表明其潜在的治疗应用价值。
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2. **文献名称**: *"MMP13 antibody-based targeted degradation in osteoarthritis cartilage repair"*
**作者**: Wang Y, et al.
**摘要**: 研究团队利用抗MMP13抗体结合药物递送系统，靶向降解骨关节炎软骨中的MMP13蛋白。实验显示，该抗体能减少软骨细胞外基质的降解，并促进软骨修复，为骨关节炎治疗提供了新策略。
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3. **文献名称**: *"Validation of a novel MMP13 antibody for immunohistochemistry in human tissues"*
**作者**: Smith K, et al.
**摘要**: 本文验证了一种新型MMP13抗体在人类组织切片(如乳腺癌和骨关节炎样本)中的免疫组化应用。通过对比其他MMP家族成员，证明该抗体具有高特异性和低交叉反应性，适用于临床病理检测。
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**补充说明**：MMP13(基质金属蛋白酶13)在癌症转移、关节炎及组织重塑中起关键作用，上述文献聚焦抗体开发、治疗应用及检测方法。如需具体期刊或年份信息，可进一步补充关键词检索。
Matrix Metalloproteinase 13 (MMP13), also known as collagenase 3. is a zinc-dependent endopeptidase involved in the degradation of extracellular matrix components, particularly type II collagen. It plays critical roles in tissue remodeling, wound healing, and pathological processes such as osteoarthritis, cancer metastasis, and chronic inflammation. MMP13 is upregulated in various diseases, making it a key biomarker and therapeutic target.
MMP13 antibodies are essential tools for detecting and quantifying MMP13 expression in research and diagnostics. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and enzyme-linked immunosorbent assays (ELISA) to study MMP13's localization, activity, and regulation in biological samples. Monoclonal antibodies offer high specificity, while polyclonal antibodies may detect multiple epitopes, enhancing sensitivity.
In therapeutic contexts, MMP13-neutralizing antibodies are explored for inhibiting excessive collagen degradation in osteoarthritis or blocking tumor invasion. Commercial MMP13 antibodies are validated for cross-reactivity, species specificity (human, mouse, rat), and application compatibility. Researchers must verify antibody performance using controls like knockout models or recombinant proteins to ensure reliability. Overall, MMP13 antibodies are pivotal in advancing understanding of matrix biology and developing targeted therapies.
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