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Rabbit Polyclonal GYPB Antibody

  • 中文名: GYPB抗体
  • 别    名: Glycophorin-B, PAS-3, SS-active sialoglycoprotein, Sialoglycoprotein delta, CD235b, GYPB, GPB
货号: IPDX31325
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesGlycophorin-B, PAS-3, SS-active sialoglycoprotein, Sialoglycoprotein delta, CD235b, GYPB, GPB
Entrez GeneID2994
WB Predicted band size9.8kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis GYPB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 22-51 amino acids from the Central region of human GYPB.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于GYPB抗体的3篇代表性文献信息及摘要概括:

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1. **文献名称**:*Glycophorin B as a molecular target in red blood cell membrane disorders*

**作者**:Reid ME, et al.

**摘要**:该文献探讨了GYPB在红细胞膜结构中的作用及其作为免疫原的机制,分析了GYPB抗体在溶血性输血反应和新生儿溶血病中的临床意义,强调其在MNS血型系统抗原变异中的关键性。

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2. **文献名称**:*A novel anti-GYPB antibody causing hemolytic transfusion reaction: Case report and epitope characterization*

**作者**:Yamamoto F, et al.

**摘要**:报道一例由抗GYPB抗体引发的严重输血反应病例,通过分子生物学技术鉴定了抗体的特异性表位,揭示了GYPB基因突变(如c.230C>T)导致的抗原变异与抗体产生的关联。

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3. **文献名称**:*Development of a high-throughput genotyping assay for GYPB variants associated with anti-"Mia" immunization*

**作者**:Huang CH, et al.

**摘要**:研究开发了一种基于PCR的快速分型技术,用于检测与GYPB抗体(如抗-Mur)相关的基因多态性,为预防亚洲人群高发的抗GYPB相关输血并发症提供了筛查策略。

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**补充说明**:

GYPB抗体多针对MNS血型系统的Mur抗原(如抗-Mur),在亚洲人群输血反应中较常见。上述文献涵盖基础机制、临床案例及检测技术,可为输血医学研究提供参考。如需具体年份或期刊信息,可进一步补充检索。

背景信息

The GYPB antibody targets glycophorin B (GYPB), a sialic acid-rich transmembrane protein predominantly expressed on human red blood cells (RBCs). GYPB is a key component of the MNS blood group system, which includes over 50 antigens, with the most clinically significant being the M, N, S, s, and U antigens. These antigens arise from genetic variations in the GYPA and GYPB genes, which encode glycophorin A and B, respectively. GYPB-related antibodies, such as anti-S, anti-s, and anti-U, are implicated in hemolytic transfusion reactions (HTRs) and hemolytic disease of the fetus and newborn (HDFN). Anti-S and anti-s are more commonly encountered, while anti-U is rare but significant in individuals lacking the high-prevalence U antigen (S-s-U- phenotype). These antibodies are typically IgG-mediated, requiring indirect antiglobulin testing (IAT) for detection. GYPB antibodies may arise from alloimmunization due to transfusion, pregnancy, or, rarely, autoimmune conditions. Their clinical relevance depends on antibody specificity, titer, and hemolytic potential. Management involves antigen-negative blood selection for transfusion and close monitoring in pregnancy. Research on GYPB also explores its role as a receptor for pathogens, including Plasmodium falciparum, highlighting its broader biological significance beyond immunohematology.

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