| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Amphoterin-induced protein 1, AMIGO-1, Alivin-2, AMIGO1 (HGNC:20824) |
| Entrez GeneID | 57463 |
| WB Predicted band size | 55.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This AMIGO1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 386-415 amino acids from the C-terminal region of human AMIGO1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与AMIGO1抗体相关的文献摘要，供参考：
1. **文献名称**：AMIGO1 modulates oligodendrocyte development and myelination
**作者**：Kuja-Panula J et al. (2016)
**摘要**：研究利用AMIGO1抗体通过免疫组化发现其在少突胶质细胞中的表达，揭示AMIGO1通过调节细胞黏附和信号通路促进髓鞘形成，为多发性硬化症机制提供新线索。
2. **文献名称**：AMIGO1 is a potential therapeutic target in pancreatic cancer
**作者**：Chen Y et al. (2020)
**摘要**：通过Western blot和免疫荧光实验(使用AMIGO1抗体)，发现AMIGO1在胰腺癌中高表达，促进肿瘤侵袭和EMT过程，提示其作为预后标志物和药物靶点的潜力。
3. **文献名称**：Structural basis of AMIGO1-mediated cell adhesion
**作者**：Park D et al. (2018)
**摘要**：结合AMIGO1抗体的共聚焦显微成像，解析AMIGO1胞外结构域与神经元表面受体的互作机制，阐明其在轴突导向中调控突触可塑性的分子基础。
*注：以上文献为虚拟示例，实际研究需通过PubMed等数据库检索具体文章。如需实验级抗体应用文献，建议补充抗体货号或研究场景细化检索。*
The AMIGO1 (Amphoterin-Induced Gene and ORF) antibody targets a protein encoded by the *AMIGO1* gene, a member of the AMIGO family (AMIGO1. AMIGO2. AMIGO3) involved in cell adhesion, axon guidance, and neuronal survival. AMIGO1 is a type I transmembrane protein containing leucine-rich repeats (LRRs), an immunoglobulin-like domain, and a cytoplasmic tail, enabling interactions with other molecules such as LAR family receptor tyrosine phosphatases. It plays critical roles in nervous system development, particularly in hippocampal neuron survival and axon fasciculation, likely through modulating AKT signaling pathways.
Beyond neurobiology, AMIGO1 is implicated in cancer, with overexpression observed in glioblastoma, colorectal cancer, and other malignancies, where it may promote tumorigenesis and metastasis. The AMIGO1 antibody is widely used in research to study its expression patterns, subcellular localization, and functional mechanisms via techniques like Western blotting, immunohistochemistry, and flow cytometry. In cancer studies, it helps assess AMIGO1’s potential as a prognostic biomarker or therapeutic target. In neuroscience, it aids in exploring its role in neurodegenerative and neuroinflammatory disorders. Commercial AMIGO1 antibodies are validated for specificity across human, mouse, and rat models, supporting diverse experimental applications.
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