| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein Smaug homolog 2, Smaug 2, hSmaug2, Sterile alpha motif domain-containing protein 4B, SAM domain-containing protein 4B, SAMD4B, SMAUG2 |
| Entrez GeneID | 55095 |
| WB Predicted band size | 75.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SAMD4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 414-442 amino acids from the C-terminal region of human SAMD4B. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SAMD4B抗体的参考文献示例(注：部分内容可能为模拟，实际文献需通过学术数据库核实)：
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1. **标题**: "Characterization of a Novel Monoclonal Antibody Against SAMD4B for Studying Its Role in mRNA Regulation"
**作者**: Li X, et al.
**摘要**: 该研究开发了一种针对SAMD4B蛋白N端的单克隆抗体，验证其在免疫印迹(Western blot)和免疫沉淀(IP)中的特异性。研究发现SAMD4B通过与Argonaute蛋白相互作用参与miRNA介导的mRNA沉默通路。
2. **标题**: "SAMD4B Expression in Neural Development: Insights from Immunohistochemical Analysis"
**作者**: Smith J, et al.
**摘要**: 利用兔源多克隆SAMD4B抗体，研究在小鼠脑组织中的表达模式。结果显示SAMD4B在神经元前体细胞中高表达，提示其可能通过调控RNA稳定性影响神经分化。
3. **标题**: "Commercial Antibody Validation for SAMD4B in Cancer Cell Lines"
**作者**: Garcia R, et al.
**摘要**: 评估了三种市售SAMD4B抗体的特异性，通过CRISPR敲除细胞系验证抗体可靠性。研究发现部分抗体存在非特异性结合，强调抗体验证在肿瘤蛋白质组学研究中的重要性。
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**备注**：以上文献为示例性质，实际研究中可查阅PubMed、Web of Science等平台，或联系抗体供应商(如Abcam、Santa Cruz)获取技术文档。若研究较少，建议扩展检索SAMD4B的功能研究文献，其中可能包含抗体使用信息。
The SAMD4B antibody is a research tool designed to detect and study the SAM domain-containing protein 4B (SAMD4B), a member of the SAMD4 family. SAMD4B is a conserved RNA-binding protein characterized by its sterile alpha motif (SAM) domain, which mediates protein-protein and protein-RNA interactions. It plays a regulatory role in post-transcriptional gene expression, particularly in mRNA stability, translation, and localization. SAMD4B is implicated in cellular processes such as cell differentiation, apoptosis, and stress responses, with emerging links to neurological disorders, cancer, and metabolic diseases.
The antibody is typically generated in host species like rabbits or mice using immunogenic peptide sequences derived from SAMD4B. It enables researchers to investigate SAMD4B's expression, localization, and function through techniques like Western blotting, immunohistochemistry, immunofluorescence, and co-immunoprecipitation. Specificity is validated using knockout controls or siRNA-mediated silencing.
Studies utilizing SAMD4B antibodies have revealed its role in regulating tumor suppressor pathways, synaptic plasticity, and viral RNA interactions. Dysregulation of SAMD4B has been associated with glioblastoma progression, Alzheimer's disease pathology, and metabolic syndrome, highlighting its therapeutic and diagnostic potential. Commercial SAMD4B antibodies often include validation data across multiple applications and species to ensure reproducibility in experimental models.
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