| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Syntaxin-17, STX17 |
| Entrez GeneID | 55014 |
| WB Predicted band size | 33.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This STX17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human STX17. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇涉及STX17(N-term)抗体的文献摘要概括(虚构示例，仅供格式参考)：
1. **文献名称**: "STX17调控自噬体-溶酶体融合的分子机制"
**作者**: Tamura N et al.
**摘要**: 本研究通过使用STX17 (N-term)特异性抗体，证实STX17通过其N端结构域与ATG14L和SNAP29相互作用，介导自噬体成熟阶段的膜融合过程(Nature, 2013)。
2. **文献名称**: "STX17在肿瘤转移中的双重作用"
**作者**: Wang Q et al.
**摘要**: 利用STX17-N端抗体进行免疫共沉淀，发现STX17通过调控EGFR内吞途径影响乳腺癌细胞迁移，其表达水平与患者预后相关(Cell Reports, 2017)。
3. **文献名称**: "STX17介导线粒体-内质网膜接触的动态变化"
**作者**: Hamasaki M et al.
**摘要**: 通过STX17 (N-term)抗体的亚细胞定位分析，揭示STX17在维持线粒体与内质网间钙离子交换及脂质转运中的关键作用(PNAS, 2015)。
注：以上文献为示例性内容，实际引用需以真实文献为准。建议通过PubMed或Web of Science以“STX17 antibody N-terminal”为关键词检索最新研究。
The STX17 (N-term) antibody is a targeted reagent used to detect Syntaxin 17 (STX17), a member of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) family involved in membrane fusion processes. STX17 is characterized by its N-terminal transmembrane domain and plays critical roles in autophagy, particularly in autophagosome-lysosome fusion and mitochondrial dynamics. The antibody specifically recognizes the N-terminal region of STX17. enabling researchers to study its expression, localization, and function in cellular pathways.
STX17 is essential for autophagosome maturation, where it interacts with other SNARE proteins like SNAP29 and VAMP8 to mediate membrane fusion. Dysregulation of STX17 has been linked to neurodegenerative diseases, cancer, and metabolic disorders. The STX17 (N-term) antibody is widely used in techniques such as Western blotting, immunofluorescence, and immunoprecipitation to investigate these mechanisms. Its specificity makes it valuable for distinguishing STX17 isoforms or post-translational modifications in different experimental models, including cell lines and tissue samples.
Research using this antibody has advanced understanding of autophagy-related pathways and organelle crosstalk. For example, studies highlight STX17’s role in suppressing tumor growth in melanoma and its involvement in mitochondrial quality control. Validated in peer-reviewed studies, the antibody remains a key tool for exploring STX17’s multifaceted contributions to cellular homeostasis and disease.
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