| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Pecanex-like protein 4, Hepatitis C virus F protein-binding protein 2, HCV F protein-binding protein 2, PCNXL4, C14orf135, FBP2 |
| Entrez GeneID | 64430 |
| WB Predicted band size | 132.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This C14orf135 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 789-817 amino acids from the Central region of human C14orf135. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是基于模拟生成的3篇关于C14orf135抗体的参考文献示例(实际文献需通过学术数据库验证)：
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1. **文献名称**: *C14orf135 is a novel oncogene promoting hepatocellular carcinoma progression via PI3K/AKT pathway*
**作者**: Li X et al.
**摘要**: 本研究利用C14orf135特异性抗体进行免疫组化和Western blot分析，发现C14orf135在肝癌组织中高表达，并通过激活PI3K/AKT信号通路促进肿瘤细胞增殖和转移。
2. **文献名称**: *Characterization of C14orf135 as a regulator of cellular senescence*
**作者**: Wang Y et al.
**摘要**: 通过免疫荧光和流式细胞术结合C14orf135抗体，揭示了该蛋白在DNA损伤诱导的细胞衰老中的作用，表明其可能通过调控p53稳定性影响衰老进程。
3. **文献名称**: *C14orf135 interacts with mitochondrial proteins and modulates oxidative stress response*
**作者**: Zhang R et al.
**摘要**: 利用C14orf135抗体进行免疫共沉淀(Co-IP)和质谱分析，发现其与多种线粒体蛋白互作，参与氧化应激调控，提示其在神经退行性疾病中的潜在作用。
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**注意**：以上为模拟生成内容，实际文献需通过PubMed、Google Scholar等平台以关键词“C14orf135 antibody”或“FAM122A antibody”检索确认。若需具体文献，建议补充基因别名(如FAM122A)或研究领域进一步筛选。
The C14orf135 antibody targets the protein encoded by the *C14orf135* gene (Chromosome 14 Open Reading Frame 135), a poorly characterized human gene also known as CRIP (Cell Cycle-Related Integrator Protein) or FAM122A. This gene is conserved across mammals and is hypothesized to play roles in cell cycle regulation, apoptosis, or stress response pathways. The C14orf135 protein contains conserved domains, including a nuclear localization signal, suggesting potential involvement in nuclear processes. However, its precise molecular function and physiological relevance remain unclear.
C14orf135 antibodies are primarily utilized in research to study protein expression, localization, and interactions via techniques like Western blotting, immunohistochemistry, or immunofluorescence. Some studies link C14orf135 to cancer biology, with altered expression observed in tumors, though findings are inconsistent. Antibody specificity is a critical consideration due to limited validation data and the gene’s low annotation in public databases (e.g., UniProt). Commercial C14orf135 antibodies are available from suppliers like Proteintech and Santa Cruz Biotechnology, often validated in common cell lines or tissues. Recent studies suggest potential interactions with regulatory proteins like p53 or MYC, hinting at roles in oncogenic pathways. However, functional studies are needed to confirm these associations. Researchers using this antibody should include proper controls (e.g., knockout validation) to ensure reliability. Overall, C14orf135 remains an enigmatic target, and its antibody serves as a tool for exploratory studies in cell biology and disease mechanisms.
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