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Rabbit Polyclonal SIDT2 Antibody

  • 中文名: SIDT2抗体
  • 别    名: SID1 transmembrane family member 2, SIDT2
货号: IPDX31316
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesSID1 transmembrane family member 2, SIDT2
Entrez GeneID51092
WB Predicted band size94.5kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenThis SIDT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 418-447 amino acids from the Central region of human SIDT2.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于SIDT2抗体的3篇参考文献示例(注:部分信息为模拟,实际文献可能需要进一步检索验证):

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1. **标题**: *SIDT2 mediates lysosomal membrane protein transport and is essential for cellular homeostasis*

**作者**: Nguyen T. et al. (2017)

**摘要**: 本研究利用SIDT2特异性抗体,通过免疫印迹和免疫荧光技术,揭示了SIDT2在溶酶体膜蛋白转运中的关键作用。敲除SIDT2导致细胞自噬功能受损,提示其与代谢疾病相关。

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2. **标题**: *SIDT2-dependent RNA translocation regulates mitochondrial dynamics*

**作者**: Zhang L. et al. (2020)

**摘要**: 通过开发新型SIDT2多克隆抗体,作者发现SIDT2通过介导特定RNA的跨膜转运调控线粒体分裂。抗体阻断实验表明,SIDT2功能缺失会引发线粒体功能障碍。

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3. **标题**: *Development of a monoclonal antibody against human SIDT2 for cancer biomarker studies*

**作者**: Lee S. et al. (2019)

**摘要**: 报道了一种高特异性抗人SIDT2单克隆抗体的制备,并验证其在组织切片中的免疫组化应用。研究发现SIDT2在多种肿瘤中异常表达,可能与癌症进展相关。

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**注意**:以上文献信息为示例性质,部分内容可能基于真实研究概括,但具体标题和作者需通过PubMed、Google Scholar等平台以"SIDT2 antibody"等关键词检索确认。如需实际文献,建议使用学术数据库进一步查询。

背景信息

The SIDT2 (SID1 Transmembrane Family Member 2) antibody is a tool used to study the SIDT2 protein, a member of the conserved SID-1 family implicated in nucleic acid transport and transmembrane signaling. SIDT2 is primarily localized to lysosomal and endosomal membranes and is suggested to play roles in cellular processes such as autophagy, lipid metabolism, and RNA/DNA uptake. Unlike its homolog SIDT1. which is linked to systemic RNA interference, SIDT2 is hypothesized to mediate lysosome-mitochondria crosstalk or regulate lysosomal acidification, though its precise molecular mechanisms remain under investigation. Research utilizing SIDT2 antibodies has focused on detecting protein expression, subcellular localization, and interactions in various tissues. Studies link SIDT2 to metabolic regulation, neurodegenerative diseases, and cancer progression, with evidence suggesting its involvement in cholesterol homeostasis and amyloid-beta clearance in Alzheimer’s models. The antibody is commonly applied in techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore these pathways. Despite its emerging significance, SIDT2's full functional spectrum and disease relevance require further elucidation, driving ongoing research using targeted antibody-based approaches.

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