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Rabbit Polyclonal GRINA Antibody

  • 中文名: GRINA抗体
  • 别    名: Protein lifeguard 1, Glutamate [NMDA] receptor-associated protein 1, NMDA receptor glutamate-binding subunit, Putative MAPK-activating protein PM02, Transmembrane BAX inhibitor motif-containing protein 3, GRINA, LFG1, NMDARA1, TMBIM3
货号: IPDX31310
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesProtein lifeguard 1, Glutamate [NMDA] receptor-associated protein 1, NMDA receptor glutamate-binding subunit, Putative MAPK-activating protein PM02, Transmembrane BAX inhibitor motif-containing protein 3, GRINA, LFG1, NMDARA1, TMBIM3
Entrez GeneID2907
WB Predicted band size41.2kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis GRINA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 131-158 amino acids from the Central region of human GRINA.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于GRINA抗体的3篇模拟参考文献,格式包括文献名称、作者及简要摘要:

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1. **文献名称**: "GRINA Antibody-Based Detection of NMDA Receptor Complex in Neurodegenerative Disorders"

**作者**: Smith, J.R., et al.

**摘要**: 该研究开发了一种特异性GRINA抗体,用于检测阿尔茨海默病模型小鼠脑组织中的NMDA受体复合物。结果表明,GRINA表达水平与突触功能损伤显著相关,提示其作为生物标志物的潜力。

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2. **文献名称**: "GRINA Expression in Glioblastoma: A Novel Antibody for Therapeutic Targeting"

**作者**: Chen, L., & Wang, H.

**摘要**: 通过新型GRINA单克隆抗体,研究发现胶质母细胞瘤中GRINA蛋白高表达,并验证了抗体介导的靶向治疗可抑制肿瘤细胞增殖,为癌症治疗提供了新策略。

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3. **文献名称**: "The Role of GRINA in Cellular Stress Response: Insights from Knockdown and Antibody Studies"

**作者**: Müller, T., et al.

**摘要**: 利用siRNA敲低GRINA及特异性抗体检测,揭示GRINA在调节内质网应激中的关键作用。实验表明,GRINA缺失会加剧细胞凋亡,提示其参与应激保护机制。

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*注:以上文献为模拟内容,实际引用时建议通过PubMed或Google Scholar检索真实文献。*

背景信息

The GRINA (GluN1 or Transmembrane BAX Inhibitor Motif-containing 3) antibody is primarily used to study the GRINA protein, a member of the TMBIM family involved in regulating cellular survival and stress responses. GRINA localizes to the Golgi apparatus and endoplasmic reticulum, where it inhibits apoptosis by interacting with pro-apoptotic proteins like BAX, modulating calcium homeostasis, and mitigating endoplasmic reticulum stress. Its overexpression is linked to cancer progression, neuroprotection, and therapy resistance. Researchers employ GRINA antibodies in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to assess protein expression levels, subcellular localization, and functional roles in diseases. Studies focus on GRINA's dual roles in promoting tumor cell survival (e.g., glioblastoma, colorectal cancer) and its neuroprotective effects in conditions like Alzheimer's disease. Additionally, GRINA is implicated in psychiatric disorders, with altered expression observed in schizophrenia and depression. The antibody aids in exploring therapeutic targets, particularly in understanding chemoresistance mechanisms and developing strategies to sensitize cancer cells to treatment. Its clinical relevance extends to potential biomarkers for disease prognosis or therapeutic response monitoring.

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