首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal PTPLA(N-term) Antibody

  • 中文名: PTPLA (N-term)抗体
  • 别    名: Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1, 3-hydroxyacyl-CoA dehydratase 1, HACD1, Cementum attachment protein, Protein-tyrosine phosphatase-like member A, PTPLA, HACD1
货号: IPDX31293
Price: ¥1180
数量:
大包装询价

验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesVery-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1, 3-hydroxyacyl-CoA dehydratase 1, HACD1, Cementum attachment protein, Protein-tyrosine phosphatase-like member A, PTPLA, HACD1
Entrez GeneID9200
WB Predicted band size32.4kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis PTPLA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-66 amino acids from the N-terminal region of human PTPLA.
FormulationPurified antibody in PBS with 0.05% sodium azide.

+ +

参考文献

以下是关于PTPLA (N-term)抗体的3篇参考文献示例(注:文献信息为模拟,实际引用需核实):

---

1. **文献名称**:*Characterization of a Novel N-terminal Specific Antibody for PTPLA in Adipocyte Differentiation*

**作者**:Smith JL, et al.

**摘要**:本研究开发了一种针对PTPLA蛋白N端的高特异性多克隆抗体,验证了其在Western blot和免疫荧光中的适用性。研究揭示了PTPLA在脂肪细胞分化中的潜在作用,并通过抗体阻断实验证明其与脂质代谢通路相关。

---

2. **文献名称**:*PTPLA Expression in Liver Regeneration: Insights from Immunohistochemical Staining Using an N-terminal Antibody*

**作者**:Chen R, et al.

**摘要**:利用抗PTPLA N端抗体进行免疫组化分析,发现PTPLA在小鼠肝脏再生过程中表达显著上调。研究提示PTPLA可能通过调控酪氨酸磷酸化参与肝细胞增殖,为肝脏修复机制提供了新视角。

---

3. **文献名称**:*Development of a Monoclonal Antibody Targeting the N-terminus of PTPLA and Its Application in Cancer Biomarker Screening*

**作者**:Garcia M, et al.

**摘要**:报道了一种针对PTPLA N端的单克隆抗体的制备与验证,证实其可特异性识别多种癌细胞系中的PTPLA蛋白。通过ELISA和流式细胞术分析,发现PTPLA在结直肠癌组织中高表达,提示其作为肿瘤标志物的潜力。

---

如需真实文献,建议在PubMed或Web of Science中检索关键词 **"PTPLA antibody N-terminal"** 或结合具体研究领域(如代谢、癌症)进一步筛选。

背景信息

The PTPLA (N-term) antibody is designed to target the N-terminal region of Protein Tyrosine Phosphatase-like A (PTPLA), a protein encoded by the PTPLA gene. PTPLA, also known as VPDP or hVDP, belongs to the protein tyrosine phosphatase (PTP) family but lacks catalytic activity due to amino acid substitutions in its conserved phosphatase domain. It is primarily expressed in tissues such as the heart, skeletal muscle, and adipose, suggesting roles in cellular differentiation, lipid metabolism, or energy homeostasis. While its exact biological function remains under investigation, PTPLA has been implicated in adipocyte differentiation and endoplasmic reticulum (ER) stress responses. The N-terminal-specific antibody enables researchers to distinguish PTPLA from other PTP family members and study its expression, localization, and interactions. It is commonly used in applications like Western blotting, immunohistochemistry, and immunofluorescence to investigate PTPLA’s involvement in metabolic disorders, obesity-related pathways, or tissue-specific regulatory mechanisms. Commercial antibodies are typically raised in hosts like rabbits or mice, with validation in knockout models to confirm specificity. Ongoing research aims to clarify PTPLA’s molecular mechanisms and potential therapeutic relevance.

客户数据及评论

折叠内容

大包装询价

×