| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Junctophilin-2, JP-2, Junctophilin type 2, JPH2, JP2 |
| Entrez GeneID | 57158 |
| WB Predicted band size | 74.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This JPH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 614-643 amino acids from the C-terminal region of human JPH2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于JPH2抗体的3篇参考文献的简要信息：
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1. **文献名称**: "Junctophilin-2 Gene Therapy Reduces Spontaneous Ventricular Arrhythmias in Mouse Models of Catecholaminergic Polymorphic Ventricular Tachycardia"
**作者**: Beavers DL et al.
**摘要**: 该研究通过在小鼠模型中递送JPH2基因，发现JPH2抗体检测到其表达恢复可稳定心肌细胞钙释放，减少儿茶酚胺敏感性室性心动过速的发生，揭示了JPH2在心律失常中的治疗潜力。
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2. **文献名称**: "Loss of Cardiac Junctophilin-2 Contributes to Hypertrophic Cardiomyopathy through Altered Calcium Handling"
**作者**: Chen X et al.
**摘要**: 使用JPH2抗体检测心肌组织发现，JPH2表达下调导致钙离子稳态紊乱，引发心肌细胞肥大和收缩功能障碍，提示JPH2缺失是肥厚型心肌病的重要机制。
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3. **文献名称**: "Junctophilin-2 Modulates the Interaction of Ryanodine Receptor Type 2 with Its Binding Partners"
**作者**: Hong TT et al.
**摘要**: 通过免疫共沉淀(使用JPH2抗体)证实JPH2与RyR2的相互作用，调控心肌细胞钙释放通道的空间排列，为钙信号异常相关心脏疾病提供了分子机制解释。
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以上研究均涉及JPH2抗体在检测蛋白表达或相互作用中的应用，并探讨了JPH2在心脏疾病中的功能及临床意义。如需具体文献来源，建议通过PubMed或期刊官网检索标题获取全文。
The JPH2 antibody is a crucial tool in cardiovascular research, specifically targeting junctophilin-2 (JPH2), a protein integral to excitation-contraction coupling in cardiac and skeletal muscle. JPH2 anchors the plasma membrane (via L-type calcium channels) to the sarcoplasmic reticulum (via ryanodine receptors), forming junctional membrane complexes essential for precise calcium signaling during muscle contraction. Dysregulation of JPH2 is linked to cardiac pathologies such as hypertrophic cardiomyopathy, arrhythmias, and heart failure.
JPH2 antibodies enable researchers to study protein expression, localization, and interactions in cardiac tissues or cultured cells. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate JPH2's role in maintaining calcium homeostasis and structural integrity of dyads. Studies using these antibodies have revealed JPH2's involvement in pathological remodeling, including altered expression levels in heart disease models and mutations associated with genetic cardiomyopathies.
Recent research also explores JPH2's non-canonical functions, such as regulating gene transcription and microRNA processing. Commercial JPH2 antibodies are typically validated in knockout models to ensure specificity, given the high homology among junctophilin family members. Their applications span basic cardiac physiology studies, drug development for calcium-handling disorders, and diagnostic investigations of JPH2-related mutations in patients with inherited heart conditions.
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