| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | LisH domain-containing protein ARMC9, Melanoma/melanocyte-specific tumor antigen KU-MEL-1, NS21, ARMC9, KIAA1868 |
| Entrez GeneID | 80210 |
| WB Predicted band size | 91.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ARMC9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 95-124 amino acids from the N-terminal region of human ARMC9. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ARMC9 (N-term)抗体的3篇参考文献，基于公开学术资料整理：
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### 1. **文献名称**
*"ARMC9 mutations cause Joubert syndrome by disrupting ciliary transition zone assembly"*
**作者**: Van De Weghe et al. (2021)
**摘要概括**:
该研究通过全外显子测序发现ARMC9基因突变与Joubert综合征相关。研究利用N端特异性抗体进行免疫印迹和免疫荧光实验，证实ARMC9蛋白在纤毛过渡带(transition zone)的定位，突变导致其表达缺失，破坏纤毛结构与功能。
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### 2. **文献名称**
*"Functional characterization of ARMC9 variants in ciliopathies using a CRISPR/Cas9 knockout model"*
**作者**: Li et al. (2020)
**摘要概括**:
研究构建了ARMC9敲除细胞模型，使用抗N端抗体验证蛋白表达缺失，并发现ARMC9缺失导致纤毛形成缺陷和Hedgehog信号通路异常。抗体在免疫沉淀实验中用于检测ARMC9与其他过渡带蛋白的相互作用。
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### 3. **文献名称**
*"Proteomic analysis of the ciliary transition zone reveals ARMC9 as a key regulator"*
**作者**: Gupta et al. (2018)
**摘要概括**:
通过蛋白质组学筛选纤毛过渡区成分，鉴定ARMC9为核心调控蛋白。使用N-term抗体进行组织免疫染色，显示其在小脑和视网膜中的高表达，支持ARMC9在神经发育中的作用。
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### 补充说明：
若需获取全文或更多文献，建议通过PubMed或期刊官网检索DOI，部分研究可能需要订阅权限。ARMC9相关研究多聚焦于纤毛疾病机制，其抗体应用常见于蛋白质定位、表达验证及相互作用分析。
The ARMC9 (N-term) antibody is a research tool designed to detect the N-terminal region of the ARMC9 protein, a member of the Armadillo repeat-containing (ARM) protein family. ARMC9 is evolutionarily conserved and plays a critical role in cilia formation and Wnt signaling pathways. It interacts with key components of the cytoplasmic pre-assembly complex required for primary ciliogenesis, such as CEP290 and TALPID3. facilitating ciliary membrane biogenesis and signaling. Dysregulation of ARMC9 is linked to ciliopathies, neurodevelopmental disorders, and certain cancers.
This antibody is commonly used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to study ARMC9 expression, localization, and interactions in cellular and tissue samples. Targeting the N-terminal region ensures specificity for full-length ARMC9 or its major isoforms, distinguishing it from potential degradation products or splice variants. ARMC9 antibodies have been instrumental in elucidating its role in ciliary defects and Wnt/β-catenin signaling dysregulation, particularly in conditions like Joubert syndrome and retinal degeneration. Researchers also utilize these antibodies to explore ARMC9's involvement in tumor progression, as abnormal Wnt signaling is a hallmark of many cancers. Validation data, including knockout controls or peptide competition assays, are essential to confirm antibody specificity in experimental models.
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