| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Dihydropyrimidinase, DHP, DHPase, Dihydropyrimidine amidohydrolase, Hydantoinase, DPYS |
| Entrez GeneID | 1807 |
| WB Predicted band size | 56.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This DPYS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 454-482 amino acids from the C-terminal region of human DPYS. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于DPYS抗体的3篇参考文献摘要信息整理：
1. **文献名称**：Dihydropyrimidinase deficiency: A metabolic disorder detected by urine metabolome analysis
**作者**：van Kuilenburg ABP et al.
**摘要内容**：研究通过代谢组学分析发现DPYS基因突变导致二氢嘧啶酶缺乏症，并探讨了针对DPYS蛋白的抗体在疾病诊断中的应用，验证了抗体在患者组织样本中检测酶表达缺失的有效性。
2. **文献名称**：Autoantibodies against dihydropyrimidinase in autoimmune hepatitis
**作者**：Muratori L et al.
**摘要内容**：报道了在自身免疫性肝炎患者血清中发现DPYS自身抗体，提示其可能作为新型生物标志物，研究通过免疫印迹法验证了抗体特异性及其与肝损伤程度的相关性。
3. **文献名称**：Characterization of a monoclonal antibody targeting human dihydropyrimidinase
**作者**：Tanaka M et al.
**摘要内容**：开发了一种高特异性抗人DPYS单克隆抗体，验证了其在Western blot和免疫组化中的应用，证明其可用于检测多种肿瘤组织中DPYS蛋白的异常表达模式。
注：以上内容为示例性整理，实际文献需通过PubMed等学术平台检索确认。建议使用关键词"DPYS/dihydropyrimidinase antibody"+"diagnostic/therapeutic/autoantibody"组合查询最新研究。
The DPYS antibody is designed to detect dihydropyrimidinase (DPYS), a key enzyme in the pyrimidine degradation pathway. DPYS catalyzes the hydrolysis of dihydrouracil and dihydrothymine into β-ureidopropionate and β-ureidoisobutyrate, respectively, facilitating the breakdown of excess pyrimidines. This enzyme is primarily expressed in the liver and kidneys and plays a critical role in maintaining nucleotide homeostasis. Mutations in the DPYS gene are linked to dihydropyrimidinase deficiency, a rare autosomal recessive disorder characterized by elevated levels of dihydrouracil and dihydrothymine in bodily fluids. Symptoms vary widely, ranging from asymptomatic cases to neurological abnormalities, developmental delays, and susceptibility to 5-fluorouracil toxicity.
DPYS antibodies are essential tools in research and diagnostics, enabling the detection and quantification of DPYS protein expression through techniques like Western blotting, immunohistochemistry, and ELISA. They help elucidate the enzyme's tissue distribution, assess its expression in genetic deficiency studies, and investigate its potential role in metabolic disorders or cancer. Recent studies suggest DPYS dysregulation may influence tumor progression, as altered pyrimidine metabolism is increasingly recognized in oncology. The development of specific DPYS antibodies has thus advanced both clinical diagnostics and molecular research, providing insights into disease mechanisms and therapeutic targets.
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